Protein Info for HMPREF1078_RS00505 in Parabacteroides merdae CL09T00C40

Annotation: RecQ family ATP-dependent DNA helicase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 568 transmembrane" amino acids 48 to 69 (22 residues), see Phobius details TIGR00614: ATP-dependent DNA helicase, RecQ family" amino acids 6 to 343 (338 residues), 361.6 bits, see alignment E=3.3e-112 PF04851: ResIII" amino acids 17 to 175 (159 residues), 25.3 bits, see alignment E=2.7e-09 PF00270: DEAD" amino acids 18 to 181 (164 residues), 99.6 bits, see alignment E=3.4e-32 PF00271: Helicase_C" amino acids 217 to 324 (108 residues), 66.1 bits, see alignment E=6.4e-22 PF16124: RecQ_Zn_bind" amino acids 528 to 565 (38 residues), 33.2 bits, see alignment 1.4e-11

Best Hits

Predicted SEED Role

"ATP-dependent DNA helicase RecQ" in subsystem DNA-replication or DNA repair, bacterial RecFOR pathway

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (568 amino acids)

>HMPREF1078_RS00505 RecQ family ATP-dependent DNA helicase (Parabacteroides merdae CL09T00C40)
MHHPLQVLKHYWGYDGFRPGQAEVIDSILSGHDTLALMPTGGGKSITFQVPALANSGICL
VISPLVALMKDQVKNLQKRGILSAFISSEMPHWEILQQLDNCILGDYKFLYISPERISSE
LFQEKLKTLSSKVNLLVVDEAHCISQWGNDFRRDYRLIADIRDAIPHVQVIAVTASATAA
VVADICEQLHFRKGYRIFKTSFERKNLSFVVRKTDNKLKEICHILSAVPGSAVIYSRTRK
GVEEYAGKLRAAGISAEYFHAGLDPVLKTERQADWVKGFTRVLVATNAFGMGIDKGDVRV
VIHTEFPDSMEAYYQEAGRAGRDGKRAYAVALLGPQDITDIKRRPSNAFPTIEYIKRVYE
ALCNRFQIAEGDGEGVSVYLDEPEFLRDWHFDKGRLRSSLEILSLSNYLTFEPYPNSQPY
LRYDQPRWMMDRFLSDDSPAAKVAVEVLRNYEGLFSTGVFVSVDMLARKTGLEAREVAKV
LGYLRNVGFYYVPPRKEPRITFKMIRVPLDRLVITTASYENRLAAFKMRIEKVAEYLETH
GCRQEFISEYFGMEGTRCGCCDNCLQKR