Protein Info for HMPREF1078_RS00220 in Parabacteroides merdae CL09T00C40

Annotation: tetratricopeptide repeat protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 707 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details PF13181: TPR_8" amino acids 92 to 122 (31 residues), 16.8 bits, see alignment (E = 4e-06) amino acids 162 to 190 (29 residues), 12.4 bits, see alignment (E = 0.0001) amino acids 193 to 223 (31 residues), 12.9 bits, see alignment (E = 7e-05) amino acids 229 to 259 (31 residues), 12.3 bits, see alignment (E = 0.00011) amino acids 525 to 543 (19 residues), 13.2 bits, see alignment (E = 5.7e-05) PF13432: TPR_16" amino acids 95 to 157 (63 residues), 21.9 bits, see alignment E=1.4e-07 amino acids 199 to 256 (58 residues), 19.9 bits, see alignment 5.8e-07 amino acids 266 to 327 (62 residues), 25 bits, see alignment 1.4e-08 amino acids 517 to 558 (42 residues), 17.3 bits, see alignment 3.6e-06 amino acids 634 to 686 (53 residues), 31.1 bits, see alignment 1.9e-10 PF13174: TPR_6" amino acids 297 to 327 (31 residues), 15.5 bits, see alignment (E = 1.5e-05) PF00515: TPR_1" amino acids 511 to 544 (34 residues), 28.7 bits, see alignment (E = 5.5e-10) amino acids 630 to 662 (33 residues), 30.1 bits, see alignment (E = 2e-10) PF13414: TPR_11" amino acids 526 to 558 (33 residues), 31.5 bits, see alignment (E = 7.3e-11) amino acids 636 to 677 (42 residues), 35.2 bits, see alignment 5.3e-12

Best Hits

KEGG orthology group: None (inferred from 77% identity to pdi:BDI_0659)

Predicted SEED Role

"TPR repeat precursor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (707 amino acids)

>HMPREF1078_RS00220 tetratricopeptide repeat protein (Parabacteroides merdae CL09T00C40)
MKKAILLFIFQLCSLAMFAQINTDRVLTIGRNALYFEDYVLSIQYFNQVIKSKPWLAEPY
FYRAVAKINLDDYKGAEEDCTLCLERNPFLVQAYYARGIARQSQEKFDEAIEDYRKGLEF
KAEDRQMLVNVAVANIQKKDFKEAEKVFDELMTAHPKYSMNYLTRGAMYTEKGDTVKALA
DYDKAISMDPYYAPAYGNRAILHYQMNNMKDALADLNEAIRLNTRESGYYINRGLVRYQL
KDLRGAMADYDQVVSMDSHNLIARFNRGLLRAQIGDNNRAIEDFDVVIEIEPDNYMAYYN
RALLRYETGDYQGSVHDFDVVLRQYPNFVAGYYSRAEVKRKMHDEVGADRDYWTAYNMEQ
KKKNGNALGNAVASQNGNNIGTQLADPASKDENTREQSDKNIDKFNRLVVYDEEEVRKTK
YNSEIRGRVQDRNVRVDLEPMFVLTYYEKVDPVKKLVYYDKMVEAYNSRLVLERKLRITN
EEAALTEDQVAVHFASIDNFSARIVKNPNDVDAYFGRALDFMLVQDFTEAIKDYTKVIEL
DPDFAMAYFNRAVVRYKQLDYNMSQAASSQDDFSAMSMNLKMGKNPTVVRTPATSDPASA
SLKDNKRAYEHEMITRDYDMVIKLNPGFVYAYFNRGNLRCAQRDFRAAIQDYSEAIQRDP
EFAEAYFNRGLARLSQGDANRGIADLSKAGELGIINAYSIIKRMTSN