Protein Info for HMPREF1078_RS00210 in Parabacteroides merdae CL09T00C40

Annotation: acyl-CoA carboxylase subunit beta

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01039: Carboxyl_trans
  • amino acids 30 to 511 (482 residues), 653.6 bits, E=2e-200

Best Hits

Swiss-Prot: 55% identical to 12S_PROFR: Methylmalonyl-CoA carboxyltransferase 12S subunit from Propionibacterium freudenreichii subsp. shermanii

KEGG orthology group: None (inferred from 96% identity to pdi:BDI_0657)

MetaCyc: 53% identical to acyl CoA carboxylase carboxyltransferase subunit (Metallosphaera sedula)
Propionyl-CoA carboxylase. [EC: 6.4.1.3]; Biotin carboxylase. [EC: 6.4.1.3, 6.3.4.14]; RXN0-5055 [EC: 6.4.1.3, 6.3.4.14, 2.1.3.15]

Predicted SEED Role

"Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) / Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2); Propionyl-CoA carboxylase beta chain (EC 6.4.1.3)" in subsystem Fatty Acid Biosynthesis FASII (EC 6.4.1.2, EC 6.4.1.3)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (48/53 steps found)
• superpathway of fatty acid biosynthesis II (plant) (37/43 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
• biotin-carboxyl carrier protein assembly (4/4 steps found)
• fatty acid biosynthesis initiation (type II) (3/3 steps found)
• propanoyl CoA degradation I (3/3 steps found)
• superpathway of fatty acid biosynthesis initiation (4/5 steps found)
• 2-oxobutanoate degradation I (3/4 steps found)
• fatty acid biosynthesis initiation (type I) (1/3 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (5/10 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (9/17 steps found)
• candicidin biosynthesis (1/6 steps found)
• 3-hydroxypropanoate cycle (6/13 steps found)
• jadomycin biosynthesis (3/9 steps found)
• methylaspartate cycle (10/19 steps found)
• superpathway of candicidin biosynthesis (4/11 steps found)
• superpathway of L-methionine salvage and degradation (7/16 steps found)
• glyoxylate assimilation (3/13 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (6/18 steps found)
• superpathway of the 3-hydroxypropanoate cycle (6/18 steps found)
• mycolate biosynthesis (15/205 steps found)
• superpathway of mycolate biosynthesis (16/239 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis
• Propanoate metabolism
• Pyruvate metabolism
• Tetracycline biosynthesis
• Valine, leucine and isoleucine degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.3.15 or 6.3.4.14 or 6.4.1.2 or 6.4.1.3

Protein Sequence (515 amino acids)

>HMPREF1078_RS00210 acyl-CoA carboxylase subunit beta (Parabacteroides merdae CL09T00C40)
MTDLSKNIQALREKKAVVEMGGGEAAIEKQIAMGKLTARDRILSLLDKNSFHEYDLFVKH
DGRDFGMDKKDLPGDGVVTGTGTIFGAPVCIYAQDFTVAGGSLGLQHARKITKIMDHALK
MKCPIIGINDSGGARIQEGVGALAGYGEIFYRNTIASGVIPQISLILGPCAGGAVYSPAL
TDFVFVVENISKMFITGPNVIKTVLGEDISMEDLGGARVHAETTGNAHFYAQSEQECFEQ
VKRLVSFIPWNNQERAKVVESKEPAAVMNIEDVVPADPKQPYDVRNVIKCIVDDSDFLEV
QELWAANIVIGFGRMGGETVGFVANQPMVLAGVLDCDSADKAARFIRFCDSFNIPIITLE
DMPGYLPGVDQEHAGVIRHGAKVLYAYSEATVPKITVILRKAYGGGYIAMNSRHLGADFM
FAWPSAEIAVMGPEGAANIIFRKEIMEAEDQNAMRQEKVKEYIEKFANPYVAASKGFIDS
VIEPKETRSLLLHALKLSVLKEEYRPAKKHGLPPF