Protein Info for HMPREF1078_RS00055 in Parabacteroides merdae CL09T00C40

Annotation: ferrous iron transport protein B

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 826 transmembrane" amino acids 395 to 418 (24 residues), see Phobius details amino acids 451 to 477 (27 residues), see Phobius details amino acids 506 to 524 (19 residues), see Phobius details amino acids 535 to 560 (26 residues), see Phobius details amino acids 566 to 585 (20 residues), see Phobius details amino acids 624 to 645 (22 residues), see Phobius details amino acids 759 to 787 (29 residues), see Phobius details amino acids 795 to 818 (24 residues), see Phobius details PF04023: FeoA" amino acids 1 to 71 (71 residues), 69.4 bits, see alignment E=6.8e-23 TIGR00231: small GTP-binding protein domain" amino acids 110 to 267 (158 residues), 55.2 bits, see alignment E=7.3e-19 PF01926: MMR_HSR1" amino acids 113 to 224 (112 residues), 64 bits, see alignment E=4.1e-21 PF02421: FeoB_N" amino acids 113 to 266 (154 residues), 202.6 bits, see alignment E=7.9e-64 TIGR00437: ferrous iron transport protein B" amino acids 118 to 789 (672 residues), 628.7 bits, see alignment E=1.2e-192 PF17910: FeoB_Cyto" amino acids 285 to 378 (94 residues), 64.9 bits, see alignment E=2.2e-21 PF07670: Gate" amino acids 463 to 559 (97 residues), 92.7 bits, see alignment E=5.8e-30 amino acids 627 to 793 (167 residues), 80.5 bits, see alignment E=3.6e-26 PF07664: FeoB_C" amino acids 568 to 620 (53 residues), 73.6 bits, see alignment 2.6e-24

Best Hits

Swiss-Prot: 60% identical to FEOAB_PORGI: Fe(2+) transport protein A/Fe(2+) transporter FeoB fusion protein (feoB1) from Porphyromonas gingivalis (strain ATCC BAA-308 / W83)

KEGG orthology group: K04759, ferrous iron transport protein B (inferred from 84% identity to pdi:BDI_1461)

Predicted SEED Role

"Ferrous iron transport protein B" in subsystem Campylobacter Iron Metabolism or Iron acquisition in Vibrio or Transport of Iron

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (826 amino acids)

>HMPREF1078_RS00055 ferrous iron transport protein B (Parabacteroides merdae CL09T00C40)
MRLSELRTGEKGVIVKVMGRGAFRKRIIEMGFIRGKEVDVIQNAPLKDPIHYRVMGYDVS
LRRNDAQMIEVVSVAEFIEASTGKQENRPVDSYIQTSGKSLQAMAMHKGKTINVALVGNP
NCGKTSLFNFASGAHEHVGNYSGVTVDAKAGTFHQNGYTFKIVDLPGTYSLSAYTPEELY
VRKHLNEEQPDIVINVVDASNLERNLYLTCQLIDMDVRMVIALNMYDELERHGNKFDHNS
LSRMIGTPIVPTISKTGFGIEELFNRVIKVYEEEDPVLRHIHINYGDVLEKAIYPVRHAL
KLNGNVSKSLSKRYLAIKLLEGDPEVESFVKSMPGSETVIHERDRNVAQIETLLKEDCET
AFTNARYGFISGALRETYEQNKIKEATSTQIIDLFVTHKVLGFPIFILFMWIMFEATFRL
GEYPMEWIESFVGWIGEFVRGNMSEGPLKDLLVDGIIGGVGGVIVFLPNILILYAFISFM
EDSGYMARAAFIMDKIMHKMGLHGKSFIPLVMGFGCNVPAIMASRTIESRNSRMITMLVN
PLMSCSARLPVYVLLTGAFFPQTAGTVMLILYASGILLAVLMARLFKRFLFKDEDVPFVM
ELPPYRMPTGKSIMIHMWEKAKQYLHKMGGIILIASIIIWFLGYFPRHSENGDVFEKQIA
EVEQSDTNPEDKAETIAELERLKSMDHQQKSYIGRIGQAIQPILHPLGFDWKMSVSLLTG
MAAKEVVVSTLSVLYTGESDDSQVLTERLKQDKNAEGELVFTPLVALSFMLFVLIYFPCI
ATISAIVHESGSWKWGIFVIVYTCVLAWFVSCVVYQTGHFFMNLFN