Protein Info for HMPREF1058_RS18725 in Phocaeicola vulgatus CL09T03C04

Annotation: phosphonoacetaldehyde hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 262 TIGR01422: phosphonoacetaldehyde hydrolase" amino acids 3 to 255 (253 residues), 371 bits, see alignment E=1.3e-115 PF00702: Hydrolase" amino acids 4 to 196 (193 residues), 50.4 bits, see alignment E=3.9e-17 PF13419: HAD_2" amino acids 24 to 202 (179 residues), 54 bits, see alignment E=2.3e-18

Best Hits

Swiss-Prot: 65% identical to PHNX_BACFR: Phosphonoacetaldehyde hydrolase (phnX) from Bacteroides fragilis (strain YCH46)

KEGG orthology group: K05306, phosphonoacetaldehyde hydrolase [EC: 3.11.1.1] (inferred from 100% identity to bvu:BVU_3007)

MetaCyc: 40% identical to phosphonoacetaldehyde hydrolase subunit (Pseudomonas aeruginosa)
Phosphonoacetaldehyde hydrolase. [EC: 3.11.1.1]

Predicted SEED Role

"Phosphonoacetaldehyde hydrolase (EC 3.11.1.1)" in subsystem Phosphonate metabolism (EC 3.11.1.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.11.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9A6U6 at UniProt or InterPro

Protein Sequence (262 amino acids)

>HMPREF1058_RS18725 phosphonoacetaldehyde hydrolase (Phocaeicola vulgatus CL09T03C04)
MKKIECVIMDWAGTAVDYGCFAPVAAFLKAFAEKGLTVTMEEARGPMGMTKIDHIRELFK
LPSVTEQFKQNYNRNWTEEDVVSIYKEFEKHLFASLEEYTTPIPGVIEVIEKLKRDGIKI
GSTTGYTTAMMDIVLPGAAAHGYTTDNCVTSNNLPAGRPQPYMIYQNMIDLAIPSVQSVI
KYGDTIADIKEGVNAGVWTVGVILGSNEMGLTQEETGKLPAEELNRRMAAVRKRMYMAGA
HYVVNTIAELPEIIEIINHKMN