Protein Info for HMPREF1058_RS18060 in Phocaeicola vulgatus CL09T03C04

Annotation: efflux RND transporter periplasmic adaptor subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 407 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 36 to 374 (339 residues), 176 bits, see alignment E=4.7e-56 PF16576: HlyD_D23" amino acids 47 to 249 (203 residues), 72.8 bits, see alignment E=3.9e-24 PF13533: Biotin_lipoyl_2" amino acids 61 to 105 (45 residues), 35.1 bits, see alignment 1.4e-12 PF13437: HlyD_3" amino acids 170 to 283 (114 residues), 54.9 bits, see alignment E=2e-18

Best Hits

KEGG orthology group: K02005, HlyD family secretion protein (inferred from 100% identity to bvu:BVU_2801)

Predicted SEED Role

"Macrolide-specific efflux protein MacA" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9UKB7 at UniProt or InterPro

Protein Sequence (407 amino acids)

>HMPREF1058_RS18060 efflux RND transporter periplasmic adaptor subunit (Phocaeicola vulgatus CL09T03C04)
MEKKKMILTTAVAVVVVAGGFWMLGGPEGKSTVDFSTETVTKGNVSNFITATGTIEPVTE
VEVGTQVSGIIDKIYVDYNSVVKKGELIAEMDKVTLQSELQSAKATYDGNEAEYDYQKKL
YDRNRKLHEKQLISDMDYEETVYNFQRAQSALEQSKAALAKAERNLSYATITSPIDGVVT
SRDVEEGQTVASGFETPTLFTIAADLTKMQVVADVDEADIAGVEEGARVTFTVDAYPDDV
FEGVVRQVRLGSTNSTSSSSSTTTSTTVVTYEVVITADNPYLKLKPRLTANATIYTLTKD
NVLTVPNKALRFTPNKDIVGGRKINDCQSSHKVWTLDNNTFTAHPVKIGITDGSKTEIVS
GITENTPVVTETVVKGAMPGMEEPSAGEGERSPFMPGPPGSNKKKNK