Protein Info for HMPREF1058_RS17495 in Phocaeicola vulgatus CL09T03C04

Annotation: DUF4981 domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1063 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details PF02837: Glyco_hydro_2_N" amino acids 54 to 232 (179 residues), 123.2 bits, see alignment E=3.2e-39 PF21467: BetaGal_gal-bd" amino acids 137 to 196 (60 residues), 30.2 bits, see alignment 1.2e-10 PF00703: Glyco_hydro_2" amino acids 271 to 364 (94 residues), 45 bits, see alignment E=5.1e-15 PF02836: Glyco_hydro_2_C" amino acids 366 to 674 (309 residues), 316 bits, see alignment E=7.5e-98 PF16353: LacZ_4" amino acids 702 to 789 (88 residues), 86.7 bits, see alignment E=3.2e-28 PF02929: Bgal_small_N" amino acids 819 to 1058 (240 residues), 219.4 bits, see alignment E=1.9e-68

Best Hits

KEGG orthology group: None (inferred from 98% identity to bvu:BVU_2694)

Predicted SEED Role

"Beta-galactosidase (EC 3.2.1.23)" in subsystem Galactosylceramide and Sulfatide metabolism or Lactose and Galactose Uptake and Utilization or Lactose utilization (EC 3.2.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.23

Use Curated BLAST to search for 3.2.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9J9I4 at UniProt or InterPro

Protein Sequence (1063 amino acids)

>HMPREF1058_RS17495 DUF4981 domain-containing protein (Phocaeicola vulgatus CL09T03C04)
MRLYGLLLCGWMTVSLQAQQIHDWENHHVLQINREPARAAFVPFAKQKGDCSMSLDGMWK
FRWTPVPSERITDFYRTDFNDKDWKDFPVPANWEINGYGTPIYVSAGYPFKIDPPRVMGE
PKASYTTYKERNPVGQYRRTFTLPAGWKANGQTFLRFEGVMSAFYVWINGERIGYSQGSM
EPSEFNITCWLKPGENQIALEVYRYSDGSYLEDQDFWRFGGVHRSIHLVHTPDIRIRDYV
VRTLPAVQGNYQDFRLLIDPQLSVYRGMDGKGYTLQAVLKDADGREVVNMVGNVEDILDL
EHKAARMNEWYPQRGPRKMGRISAVIKSPQRWTAETPYLYKLELRLQNANGQTIEQVEQP
VGFRCIEIKDGQMLVNGNSVRFRGVNRHEHDPYTARVMSEERMLQDILLMKQANVNAVRT
SHYPNVSRWYELCDSLGLYVMDEADIEEHGLRGTLASTSDWHAAFLDRAVRMAERDKNHP
SVVMWSMGNESGYGPNFAAISAWLHDFDPTRPVHYEGAQGVNGEPDPKTVDVISRFYTRV
KQEYLNPGIPEGEDKERAENARWERLLEIAERTNDNRPVMTSEYAHCMGNALGNFKEYWD
EIYSNPRMLGGFIWDWVDQGIYKILPDGRRMVAYGGDFGDRPNLKAFCFNGVVMSDRETT
PKYWEVKKVYAPVKLEMEKDLQVFPKEQDVFLKEQDVLPKGLRVTNRNHHIGLEGYRCLW
TLIENGKKMKQGELALPSVEPGETGTMALPDVKINKQADVRLNVSIVLKEDALWAKAGHE
ILKEQFALNDHLMAVADGVQPGRRKSKFSVLDLWEDSYFQAFRAPTDNDKSFGNWLAKDW
KNQGLDAPQVEVITSETETQETDGTVSKKSVVEYRYAKGSIRVSSHYKIYVDGTVDLEQT
YLPQGELPELPRLGSAFVLGEEYENLSWYGRGPWENYPDRKTSCLIGRWNSKVSEQYTHY
PRPQDSGNHEDVTEVILTNKQGKGVRVTAIDRPFSFSALHYTVDDIYKTTHDCDLKPRKE
VILSLDAAVLGLGNSSCGPGVLKKYAIDKQKPHTLRVRFSLIK