Protein Info for HMPREF1058_RS17100 in Phocaeicola vulgatus CL09T03C04

Annotation: exodeoxyribonuclease III

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 252 TIGR00633: exodeoxyribonuclease III (xth)" amino acids 2 to 250 (249 residues), 336.3 bits, see alignment E=1.3e-104 TIGR00195: exodeoxyribonuclease III" amino acids 2 to 250 (249 residues), 332.2 bits, see alignment E=2.3e-103 PF03372: Exo_endo_phos" amino acids 5 to 243 (239 residues), 120.6 bits, see alignment E=8.1e-39

Best Hits

Swiss-Prot: 63% identical to EXOA_BACSU: Exodeoxyribonuclease (exoA) from Bacillus subtilis (strain 168)

KEGG orthology group: K01142, exodeoxyribonuclease III [EC: 3.1.11.2] (inferred from 100% identity to bvu:BVU_2613)

Predicted SEED Role

"Exodeoxyribonuclease III (EC 3.1.11.2)" in subsystem DNA repair, bacterial (EC 3.1.11.2)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.11.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9UIX4 at UniProt or InterPro

Protein Sequence (252 amino acids)

>HMPREF1058_RS17100 exodeoxyribonuclease III (Phocaeicola vulgatus CL09T03C04)
MLKFISWNVNGLRACYDKGFVDVFHRLEADFFCLQETKMQEGQLDAKFEGYHSYWNYAEK
KGYSGTAIFSKVKPLSVTYGLGIEEHDHEGRVITLELESFYLITVYTPNSQEELRRLDYR
MKWEDDFRAYLKKLEEKKPVIVCGDLNVAHKEIDLKNPKTNRKNAGFTDEERTKFTTLLE
SGFTDTFRYFYPEQEGIYSWWSYRFKAREKNSGWRIDYFLTSDSLKDRLKGAHIYTDIFG
SDHCPVELTIEL