Protein Info for HMPREF1058_RS15395 in Phocaeicola vulgatus CL09T03C04

Annotation: dihydroorotase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00857: dihydroorotase, multifunctional complex type
  • amino acids 15 to 430 (416 residues), 286.4 bits, E=2e-89
• PF01979: Amidohydro_1
  • amino acids 53 to 427 (375 residues), 89.6 bits, E=2.4e-29

Best Hits

KEGG orthology group: K01465, dihydroorotase [EC: 3.5.2.3] (inferred from 100% identity to bvu:BVU_2258)

Predicted SEED Role

"Dihydroorotase (EC 3.5.2.3)" in subsystem De Novo Pyrimidine Synthesis (EC 3.5.2.3)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (16/18 steps found)
• UMP biosynthesis II (6/6 steps found)
• UMP biosynthesis III (6/6 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
• UMP biosynthesis I (5/6 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.3

Sequence Analysis Tools

See I9A2R3 at UniProt or InterPro

Protein Sequence (446 amino acids)

>HMPREF1058_RS15395 dihydroorotase (Phocaeicola vulgatus CL09T03C04)
MKRTWIKNARIVNEGKIFHGSIVIENEVIAEVLAEETVPSQPCGETIDAKGYYLMPGVID
DHVHFRDPGLTHKADIHTESTAAAAGGVTSFMDMPNTTPQTTTLEALNAKFADAATKSIV
NYSFYFGATNTNADVLPTLDKSRVCGVKLFMGASTGNMLVDRMEVLRKVFANAGMLIAAH
CEEQSIISANTTAFKEKYGEDPDIKYHPQIRSAEACAYSSSLAIRLAKENNARLHILHIS
TAQELDLLEDKPLSEKKITAEACVSHLYFYDKDYETLKGRIKCNPSIKTSEDRNALRKAL
STNLIDVIGTDHAPHLLKEKEGGALKAVSGMPMIQFSLVAIMELVREGILSIEQLVQKMC
HAPAELYHIERRGYIRPGYQADLVLVNPDHEWTVTADCVLSKCGWTPMEGQKFHTRVEKT
FVNGDLVYSDNKVDQSHRGQELRFKR