Protein Info for HMPREF1058_RS15045 in Phocaeicola vulgatus CL09T03C04

Annotation: family 20 glycosylhydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 807 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF02838: Glyco_hydro_20b" amino acids 27 to 159 (133 residues), 74.7 bits, see alignment E=2.3e-24 PF00728: Glyco_hydro_20" amino acids 162 to 523 (362 residues), 414 bits, see alignment E=1.2e-127 PF13290: CHB_HEX_C_1" amino acids 570 to 623 (54 residues), 38.5 bits, see alignment 1.9e-13 PF13287: Fn3_assoc" amino acids 571 to 628 (58 residues), 67.6 bits, see alignment 1.7e-22

Best Hits

KEGG orthology group: K12373, hexosaminidase [EC: 3.2.1.52] (inferred from 100% identity to bvu:BVU_2209)

Predicted SEED Role

"Beta-hexosaminidase (EC 3.2.1.52)" in subsystem Chitin and N-acetylglucosamine utilization or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 3.2.1.52)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.52

Use Curated BLAST to search for 3.2.1.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9A418 at UniProt or InterPro

Protein Sequence (807 amino acids)

>HMPREF1058_RS15045 family 20 glycosylhydrolase (Phocaeicola vulgatus CL09T03C04)
MKKKSLPVFFVGLLMCGCQMKEVINEYNVVPLPVTMSEQQGRFYLNSDVPIVVNASQEVK
HIASGLSTTLLDIAGLKLKPTDELHENVPSIVFDSIPGMEKEAYKLSVTPQLIKITASAP
NGFYYGLQTLYQLLPVDVYCKERARNAEWSVPCVEIEDAPTFRYRGAMLDVCRHFASIDY
IKKFIDVLAAHKMNTFHWHLTDDQGWRIEIKKYPKLTEIGSQRSETMVDYFYTHYPFKYD
GKPHGGFYTQDEIKEVVAYAQSKYITVIPEIELPGHALAAIASYPELSCTPDSTYEVCKL
WGVFDQVFCPTDTFFQFMEGVMDEVVELFPSSYIHIGGDECPKTAWEQCEHCQKLIRELG
LENDITPNPVDGRKHTKEEKLQSYIVSRVEKYLNSKGRNIIGWDEILEGGLAPNATVMSW
RGVEGGMTAAKAGHDAIMTPNPYAYLDHYQEEPEIAPVTIGGYNTLKKTYSYNPVPADAD
SLVKQHIIGVQANCWAEYMPTEDNRDYQIFPRLIAISETGWTPMKKKNFTSFCNRMVEDF
QRLEAMGVKPCLNFFDVNINTRATQEGVLNVELETFYPGAQIYYTTHGEQPSIHANLYNH
PFPLDGTYDLKAAAFVNGKQIGKVTHKQLYKNLISGKKYEIMPEPKGMKGDILGENDILG
ADTVTLGLTNGKRGNNASSTPWVGISPDNNDKVTFIVDFEKTTIRKIRFGTLYNAAGGIL
PVSKAVVYVSSLDNKFEKVAEKEFTYDIKENTFRGFDEEIEFPAQEAVKVKIEFTSGGKI
RNGIDCYSPHDKSEVPSTIALDEIEIY