Protein Info for HMPREF1058_RS15030 in Phocaeicola vulgatus CL09T03C04
Annotation: phosphoglycerate kinase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 74% identical to PGK_BACTN: Phosphoglycerate kinase (pgk) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
KEGG orthology group: K00927, phosphoglycerate kinase [EC: 2.7.2.3] (inferred from 100% identity to bvu:BVU_2206)MetaCyc: 52% identical to plastidic 3-phosphoglycerate kinase (Spinacia oleracea)
Phosphoglycerate kinase. [EC: 2.7.2.3]
Predicted SEED Role
"Phosphoglycerate kinase (EC 2.7.2.3)" in subsystem Calvin-Benson cycle or Entner-Doudoroff Pathway or Glycolysis and Gluconeogenesis or Glycolysis and Gluconeogenesis, including Archaeal enzymes (EC 2.7.2.3)
MetaCyc Pathways
- superpathway of glucose and xylose degradation (16/17 steps found)
- glycolysis III (from glucose) (11/11 steps found)
- homolactic fermentation (11/12 steps found)
- glycolysis II (from fructose 6-phosphate) (10/11 steps found)
- glycolysis IV (9/10 steps found)
- superpathway of glycolysis and the Entner-Doudoroff pathway (14/17 steps found)
- gluconeogenesis I (11/13 steps found)
- glycolysis I (from glucose 6-phosphate) (11/13 steps found)
- Entner-Doudoroff pathway I (8/9 steps found)
- formaldehyde assimilation III (dihydroxyacetone cycle) (10/12 steps found)
- gluconeogenesis III (10/12 steps found)
- Bifidobacterium shunt (12/15 steps found)
- superpathway of N-acetylneuraminate degradation (17/22 steps found)
- heterolactic fermentation (14/18 steps found)
- hexitol fermentation to lactate, formate, ethanol and acetate (14/19 steps found)
- superpathway of anaerobic sucrose degradation (14/19 steps found)
- superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (19/26 steps found)
- superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (16/22 steps found)
- glycolysis VI (from fructose) (8/11 steps found)
- Calvin-Benson-Bassham cycle (9/13 steps found)
- sucrose biosynthesis I (from photosynthesis) (6/9 steps found)
- superpathway of hexitol degradation (bacteria) (12/18 steps found)
- ethene biosynthesis V (engineered) (15/25 steps found)
- oxygenic photosynthesis (9/17 steps found)
- glycerol degradation to butanol (8/16 steps found)
- 1-butanol autotrophic biosynthesis (engineered) (14/27 steps found)
- photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (13/26 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Carbon fixation in photosynthetic organisms
- Glycolysis / Gluconeogenesis
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.7.2.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See I9A2X8 at UniProt or InterPro
Protein Sequence (417 amino acids)
>HMPREF1058_RS15030 phosphoglycerate kinase (Phocaeicola vulgatus CL09T03C04) MMTIDKFNFAGKKAIVRVDFNVPLDENGKITDDTRIRGALPTLKKVLADGGSLIIMSHMG KPKGKVNAKYSLSQIVDAVSEKLGVPVQFAPDCAKAGDAAAALKPGEVLLLENLRFYPEE EGKPVGIDKEDPAYEDAKKAMKASQKEFAKTLASYADCYINDAFGTAHRKHASTAVIADY FDADNKMLGYLMEKEVQAVDNILKDIKRPFTAIMGGSKVSTKIGIIENLMDKVDNLILCG GMTYTFAKAQGGKIGNSIVEDDKLDLALDIIAKAKAKGVNLVLGSDCVAADAFSNDAHTQ VVPANNIPDGWEGLDAGPETQKAFAAAIEDAKTILWNGPAGVFEFDNFTAGSRAIAEAIA KATKNGAFSLIGGGDSVACINKFGMADQVSYISTGGGALLEAIEGKILPGVAAIKGE