Protein Info for HMPREF1058_RS13930 in Phocaeicola vulgatus CL09T03C04

Annotation: DNA polymerase III subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1265 PF02811: PHP" amino acids 6 to 222 (217 residues), 175.1 bits, see alignment E=3e-55 TIGR00594: DNA polymerase III, alpha subunit" amino acids 89 to 1138 (1050 residues), 1077.7 bits, see alignment E=0 PF07733: DNA_pol3_alpha" amino acids 400 to 668 (269 residues), 298.9 bits, see alignment E=7.4e-93 PF17657: DNA_pol3_finger" amino acids 671 to 834 (164 residues), 188.6 bits, see alignment E=1.1e-59 PF14579: HHH_6" amino acids 908 to 995 (88 residues), 98.8 bits, see alignment 3.3e-32

Best Hits

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 100% identity to bvu:BVU_1885)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9A1C2 at UniProt or InterPro

Protein Sequence (1265 amino acids)

>HMPREF1058_RS13930 DNA polymerase III subunit alpha (Phocaeicola vulgatus CL09T03C04)
MQDFVHLHVHTQYSILDGQASIPRLVDKAMADGMKGIAVTDHGDMFGIKEFFNYVNKKNS
STNSEIKDLKKRIAGLEKGTVECDNPETELVACKEKLETAKKKLFKPIFGCEMYVARRRL
FNKEGKPDQSGYHLVVLAKNEKGYHNLIKLVSKAWTEGFYMRPRTDRVELEKYHEGLIVC
TACIAGEVPRNIIAGKYEEAEEAIQWYKRVFGDDFYLELQRHKATVPRANHEAYKLQQIA
NEKLIEYSKKFNVKLVCTNDVHFVDEENAEAHDRLICLSTGKDLDDPNRMLYSKQEWMKT
RAEMNEVFADVPEALSNTVDICDQVEFYSIDHAPIMPTFAIPEDFGTEEGYRKKYTEKDL
FDEFTQDENGNVVMSEEAAKAKIEKLGGYDKLYRIKLEADYLKKLALEGAHKRYGEVLSE
EVQERIKFELHIMKTMGFPGYFLIVQDFIRAAREELDVSVGPGRGSAAGSAVAYCLGITK
IDPIAYDLLFERFLNPDRISLPDIDVDFDDDGRGRVLNWVTEKYGQEKVAHIITYGTMAT
KLAIKDVARVQKLPLSESDRLCKLVPDKIPDKKMNLPNAIAYVPELQAAEVSPDPILRDT
IKYAKMLEGNVRNTGVHACGTIICRDDITDWVPVSTADDKETGEKMLVTQYEGSVIEDTG
LIKMDFLGLKTLSIIKEAIENIKHSKGIILDIDEVDISDPPTYALYSEGRTIGTFQFESA
GMQKYLRELEPSTFEDLIAMNALYRPGPMDYIPDFIDRKHGRKPIEYDIPIMEKYLKDTY
GITVYQEQVMLLSRLLADFTRGESDALRKAMGKKLRDKLDHMKPKFIEGGRKNGHDPKVL
EKIWTDWEKFASYAFNKSHATCYSWVAYQTAFLKANYPAEYMAATMSRNISNITEITKLM
DESKATGIMTKGPDVNESYLKFSVNRKGDIRFGLGAIKGVGESAVQSILEERERNGEYKD
IFDFVQRVNLSACNRKNIENLALAGAFDSFTGIKREDFFVKNAKDETFTEVLVRYGNKYQ
MDKAAAANSLFGGENQVDIATPEIIPSPAWGDLERLNKERDLVGIYLSAHPLDEYAVILE
NVCNVHMAELADLTPLQNRDLTMGGIVTAVREGYTKTGKPYGIAKVEDYSGSAEFAFFGN
EWVEKKNFFMTGMFLFMRGKCQPKQWRQEEWEVKISTIELLPEVKEKIIEKLTVSAPLSA
LDEELITEFSALIKAHPGNAELYFHVMDEDGQMYVNLMSRTMKISVQKEIMTYLKSQPQL
SYKIN