Protein Info for HMPREF1058_RS13435 in Phocaeicola vulgatus CL09T03C04

Annotation: helix-turn-helix domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 928 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 762 to 780 (19 residues), see Phobius details PF07494: Reg_prop" amino acids 87 to 108 (22 residues), 22.6 bits, see alignment (E = 1.9e-08) amino acids 447 to 466 (20 residues), 16.6 bits, see alignment (E = 1.8e-06) PF07495: Y_Y_Y" amino acids 693 to 750 (58 residues), 31.8 bits, see alignment 2.7e-11 PF12833: HTH_18" amino acids 851 to 928 (78 residues), 77.9 bits, see alignment E=1.5e-25 PF00165: HTH_AraC" amino acids 893 to 927 (35 residues), 33.1 bits, see alignment (E = 1.1e-11)

Best Hits

KEGG orthology group: None (inferred from 98% identity to bvu:BVU_1788)

Predicted SEED Role

"DNA-binding response regulator, AraC family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I8ZYW2 at UniProt or InterPro

Protein Sequence (928 amino acids)

>HMPREF1058_RS13435 helix-turn-helix domain-containing protein (Phocaeicola vulgatus CL09T03C04)
MKSIGRIVLPIIILLLTVRINAVPVKAFDMIVRNLPNSEQLPTKELLCIFQDSEGYMWYG
TEGGGLCRDDGYTVKVFRSDFKNPGILENNSVTCIAEDGEGKIWFGTKRGAYILSKTDYE
IRALADETIKSWTITTMTATSDGTIWISTNRHLFRYNESGERTGKYILKWKGRENTVNSI
YEDKKKTVWVTQAKGGLFCYDKVKDSFISYPWPYDEYPTSMTEDHNTPYYWVTTWGKGIV
RFDPKAQDTDKMFGLQTVDNASSNSDARKLHHIIQDSVKGYLWVTAADNLYAYKITADAS
LDKVDLSRLLSADRKILTKILSDQSGNLWVTGYYPSSFIISFLPNEVLPLSMEGVKQNLG
VIASPMQFSQEKNYYWIRQKKLGLYAYDPQRERMSVVKNDRELSFFFERPSDREGIYMVR
DHSVILIRYKEDRLFESIVCAIPIKQGERIRALHDDRRGNLWIGTTYHLFRYSLEEGRLT
TVCDDVGFINAIVSSNEGVVYFATESRGLWRVSGESRLQIKDTGENYSVLTVAPDNNLWV
GTKQGNVYSYSPDTNDFISRTKDCGLTGDAVLDIKSDDDGNLWILTSQRVMVYHPGTHIF
TMMSCTDSWINLEDFQSLYKDPRGEMSVGGRGGIVTFPHYNEKKRRIPEPTVHLTSVEMN
NTSEIGVGNQEKISLSPHERNVKLFFSTFDHLNTDKVRYAYRYKQRNDNWVALPTGENSI
GLSDLSKGEFELEVRATDENGLWSKSTLTVMIQCLPAWYETGWAYLFYVLVVLSVVWGLG
RMYMKLRESMVAQTVLPLEQNPEQRHEIDPLPEEGKVEANSISASDEQLIRKALDMVEKN
LGNPEYSIEDLSRDMCMSRATLYRKITSITGSSPSDFVKNVRLRKAAELLKEGGLSIAEI
ADQVGFNTPSYFTKSFKKLFGVLPTQYK