Protein Info for HMPREF1058_RS13195 in Phocaeicola vulgatus CL09T03C04

Annotation: beta-N-acetylhexosaminidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02838: Glyco_hydro_20b
  • amino acids 25 to 150 (126 residues), 80.1 bits, E=2.3e-26
• PF00728: Glyco_hydro_20
  • amino acids 154 to 503 (350 residues), 350.7 bits, E=1.1e-108

Best Hits

KEGG orthology group: K12373, hexosaminidase [EC: 3.2.1.52] (inferred from 56% identity to bhl:Bache_0092)

Predicted SEED Role

"Beta-hexosaminidase (EC 3.2.1.52)" in subsystem Chitin and N-acetylglucosamine utilization or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 3.2.1.52)

MetaCyc Pathways

• chitin degradation II (Vibrio) (3/6 steps found)
• chitin degradation III (Serratia) (3/7 steps found)
• peptidoglycan recycling I (6/14 steps found)
• peptidoglycan recycling II (2/10 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glycosaminoglycan degradation
• Glycosphingolipid biosynthesis - ganglio series
• Glycosphingolipid biosynthesis - globo series
• Nucleotide sugars metabolism
• Other glycan degradation

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.52

Use Curated BLAST to search for 3.2.1.52

Sequence Analysis Tools

See I9J316 at UniProt or InterPro

Protein Sequence (539 amino acids)

>HMPREF1058_RS13195 beta-N-acetylhexosaminidase (Phocaeicola vulgatus CL09T03C04)
MKYIVVLLICLMWGGSLSAQQNLSALVPMPNHVEKQKGKAFVVTDKTWIVIRNASLRFEA
EELQRMLEVQMGLRLNIQIGAVKGKHIYLISNSQNEILEHYRLRVNSKKLEISAESSKGI
FYGIQTLAQLLLGDAENTAHHRVTPVLIEDSPRFAFRGLMLDVARHFLPVSDVKRFIDLM
ASFKYNVLQLHLTDDQGWRIEIKQYPQLTKIGAFRNKKGSDQGPDNGYYTQEQLKDLIAY
AAQRHVEIIPELDIPGHTAAVLAVFPEMLCQSLNTVPVQIGKTTDVMMCASNEHCYKIYQ
NILTEVAGLFPSRSIHLGGDEAVIEKNWGKCSSCQVLKEKLGYQKSSDLMNYFFGKILSI
VRKLKKEPILWCELNNIWMPADSYLFNYPKDVTLVSWRAGLTPLCQELTQKNGNSLIMAP
GEYAYLDYPQYKNDLPEYNNWGMPITTLEKTYQFDPAYGDEFSEKHIRGVLGTLWSEAIK
DFNRVTYMTYPRGLALAEAGWTQMEHRTWSSFKQRICPNLYKMMKDGISFRVPFEIFRK