Protein Info for HMPREF1058_RS12450 in Phocaeicola vulgatus CL09T03C04

Annotation: deoxyguanosinetriphosphate triphosphohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 443 TIGR01353: putative dGTPase" amino acids 25 to 436 (412 residues), 370.6 bits, see alignment E=7e-115 PF01966: HD" amino acids 62 to 127 (66 residues), 26.2 bits, see alignment E=8.7e-10 PF13286: HD_assoc" amino acids 346 to 434 (89 residues), 35.4 bits, see alignment E=1.3e-12

Best Hits

KEGG orthology group: K01129, dGTPase [EC: 3.1.5.1] (inferred from 100% identity to bvu:BVU_1408)

Predicted SEED Role

"Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1)" in subsystem Purine conversions (EC 3.1.5.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.5.1

Use Curated BLAST to search for 3.1.5.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I8ZYL8 at UniProt or InterPro

Protein Sequence (443 amino acids)

>HMPREF1058_RS12450 deoxyguanosinetriphosphate triphosphohydrolase (Phocaeicola vulgatus CL09T03C04)
MNWKQLISNKRFGMEELHEARKDDRTEFQRDYDRLIFSAPFRRLQNKTQVFPLPGSVFVH
NRLTHSLEVSCVGRSLGNDVASQLLKKHPALADSHISEIGSIVSAACLAHDLGNPPFGHS
GEKAISTYFSEGQGMALKKELSPMEWDDLTHFEGNANAFRILTHQFEGRRKGGFVMTYST
LASIVKYPFSSQLAGKKSKFGFFLSEEADYQKIAGELGIIRLSKPDEPLRYARHPLVYLV
EAADDICYQMMDIEDAHKLKLLTHDETKGLYMQFFDEKRRKRIEEVCRIVTDVNEQIAYL
RSSVIGALIKECTRVFTENEEKILTGEFEGTLIMHICSPLKEAYDNCSAIAFQRIYRSSD
VLDIELAGFRVISTLIDLMINAVCSPEKAYSQLLINRISGQYNVNAPTLYGKIQAVLDYI
SGMTDVYALDLYRKIKGNSLPAV