Protein Info for HMPREF1058_RS11500 in Phocaeicola vulgatus CL09T03C04

Annotation: DNA polymerase I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 971 PF02739: 5_3_exonuc_N" amino acids 3 to 169 (167 residues), 180.6 bits, see alignment E=4e-57 TIGR00593: DNA polymerase I" amino acids 4 to 971 (968 residues), 995.2 bits, see alignment E=1.8e-303 PF01367: 5_3_exonuc" amino acids 174 to 266 (93 residues), 113.2 bits, see alignment E=1.4e-36 PF01612: DNA_pol_A_exo1" amino acids 379 to 559 (181 residues), 111 bits, see alignment E=1.2e-35 PF00476: DNA_pol_A" amino acids 592 to 969 (378 residues), 556.4 bits, see alignment E=6.5e-171

Best Hits

KEGG orthology group: K02335, DNA polymerase I [EC: 2.7.7.7] (inferred from 100% identity to bvu:BVU_1207)

Predicted SEED Role

"DNA polymerase I (EC 2.7.7.7)" in subsystem DNA-replication or DNA Repair Base Excision (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I8ZWW3 at UniProt or InterPro

Protein Sequence (971 amino acids)

>HMPREF1058_RS11500 DNA polymerase I (Phocaeicola vulgatus CL09T03C04)
MDKLFLLDAYALIYRAYYAFIKSPRINSKGFNTSAVLGFVNTLEEVLKKENPTHIGVAFD
PAGPTFRHEAYEQYKAQREETPEVIRLSVPIIKDIIRAYRIPILEVPGYEADDVIGTLAT
EAGKRGITTYMMTPDKDYGQLVGGNVFMYRPKHTGGFEVMGIEEVKAKFDIQSPAQVIDM
LGLMGDSSDNIPGCPGVGEKTAQKLIAQYGSIENLLSHSAELKGALKTKVETNRKMIEFS
KFLATIKIDVPIALNMDELKREEPNEEELRKIFEEMEFRTLIDRVFNRDKKSAFAGTYPD
ATGNDPQGRNRTLGGSARQGNTPNGSGQLSLFGEPASNGESPASPSSPQGNLFAEFTDGG
TESEKYSNLACLDNLKYDYQLVDTEEKRTELLQNLLTKEIFSLDTETTGTDPITAELVGM
SFSYAENQAFYVPVPADRAEAQKIVNEFRPAFEKEGVLKVGQNIKYDMLVLGNYGTEVRG
PLFDTMVAHYVLQPELRHNMDYLAEIYLHYQTIHIEELIGPKGKGQKNMRDLSPEAIYKY
ACEDADVTLKLKNILEQELKTNDAEKLFYEIEMPLVPVLAYMERNGVRVDTEALKQTSEH
FTARMNQIEEEVHQLAGTDFNIASPKQVGEVLFDKLRIVEKAKKTKTGQYVTSEEVLESL
RGKHEIVGKILEHRGLKKLLGTYIDALPLLINKETGKIHTSFNQTVTATGRLSSSNPNLQ
NIPIRNEDGKEIRKAFIPDDGCEFFSADYSQIELRIMAHLSGDTNMIEAFKEGDDIHAAT
AAKVYKISIDKVTREQRSKAKTANFGIIYGISVFGLAERMNVDRKEAKELIDGYFETYPQ
IKEYMDKSIDLARGQGYIETIFGRKRYLPDINSRNSVVRGYAERNAINAPIQGSAADIIK
VAMVRIYQRFQSESIKSKMILQVHDELNFSVLPEEKEKVQKIVIEEMENAYRMQVPLRAD
CGWGSNWLEAH