Protein Info for HMPREF1058_RS11365 in Phocaeicola vulgatus CL09T03C04

Annotation: MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 458 transmembrane" amino acids 12 to 36 (25 residues), see Phobius details amino acids 51 to 71 (21 residues), see Phobius details amino acids 81 to 104 (24 residues), see Phobius details amino acids 110 to 130 (21 residues), see Phobius details amino acids 142 to 163 (22 residues), see Phobius details amino acids 169 to 189 (21 residues), see Phobius details amino acids 201 to 220 (20 residues), see Phobius details amino acids 231 to 247 (17 residues), see Phobius details amino acids 267 to 291 (25 residues), see Phobius details amino acids 299 to 321 (23 residues), see Phobius details amino acids 332 to 352 (21 residues), see Phobius details amino acids 400 to 421 (22 residues), see Phobius details amino acids 429 to 449 (21 residues), see Phobius details TIGR00711: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family" amino acids 15 to 419 (405 residues), 234.6 bits, see alignment E=1e-73 PF00083: Sugar_tr" amino acids 16 to 193 (178 residues), 39 bits, see alignment E=5.1e-14 PF07690: MFS_1" amino acids 20 to 410 (391 residues), 186.8 bits, see alignment E=5.5e-59

Best Hits

Swiss-Prot: 59% identical to YEBQ_ECOLI: Uncharacterized transporter YebQ (yebQ) from Escherichia coli (strain K12)

KEGG orthology group: K08169, MFS transporter, DHA2 family, multidrug resistance protein (inferred from 100% identity to bvu:BVU_1183)

Predicted SEED Role

"Putative transport protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9J036 at UniProt or InterPro

Protein Sequence (458 amino acids)

>HMPREF1058_RS11365 MFS transporter (Phocaeicola vulgatus CL09T03C04)
MSKEKTAFIPKQYFAVVAVLLAIMMSVLDGTIMNIALPTLAHDFDVTPSNAIWIVNAYQL
VITMTLLSFASLGDIYGYRRIFLTGISIFAGASLACALSDSFWMLTVSRIIQGFGAACVM
SVNTALIRLIYPPQILGRGMGVNAMVVAVSAAAGPSIAGSILALGSWHWLFVINIPLGLA
ALVIGHRFLPHNPASDTKHKFDKISAIANALTFGLLIYTLEGFAHAENRKFIAIQLVLLI
IIGTYFIRRQLKETTPILPVDLLKIPIFALSIGTSITSFTAQMLAMVSLPFFMQNILGYS
AVQIGLLLTPWPLATILTAPLAGRLVEKVHPGLLGGIGMAIFATGLFTLYLLPPHPAEWN
IIWRMALCGMGFGLFQTPNNVTIVSSAPTHRSGGASGMLGTARLLGQTLGTTLVALLFRM
FAEGHRAQACLLLAIFFAIAAGVVSSIRMTQASPAGKK