Protein Info for HMPREF1058_RS10745 in Phocaeicola vulgatus CL09T03C04

Annotation: sulfatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 478 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF00884: Sulfatase" amino acids 26 to 368 (343 residues), 188.4 bits, see alignment E=4e-59 PF01663: Phosphodiest" amino acids 28 to 314 (287 residues), 47.1 bits, see alignment E=5.3e-16 PF02995: DUF229" amino acids 275 to 346 (72 residues), 27.2 bits, see alignment E=3.4e-10 PF16347: SGSH_C" amino acids 318 to 465 (148 residues), 61.2 bits, see alignment E=2.8e-20

Best Hits

KEGG orthology group: None (inferred from 97% identity to bvu:BVU_1045)

Predicted SEED Role

"Choline-sulfatase (EC 3.1.6.6)" in subsystem Choline Transport or Choline and Betaine Uptake and Betaine Biosynthesis (EC 3.1.6.6)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 3.1.6.6

Use Curated BLAST to search for 3.1.6.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I8ZXD1 at UniProt or InterPro

Protein Sequence (478 amino acids)

>HMPREF1058_RS10745 sulfatase (Phocaeicola vulgatus CL09T03C04)
MKFLYKKTFFIFPFLTSIYLQAQEKPNLVFIMADQWRGDALGCLGKEPVKTPCLDQLARE
GVNFTNAVSSYPVSSPARGMLMTGMYPHKNKVTGNCNSANAPYGVELPQDARCWSDILKA
NGYQTGYIGKWHLDAPYEPYIDTYNNHGAVAWNEWCPKERRHGFDYWTAYGTYDYHLKPM
YWDTDAPRDSFYYVNQWGPEYEADKAIEYLNGHIDKTQPFALVVSMNPPHTGYELVPDRY
KEMYKNLNVEALCANRPDIPAKGTEMGDYFRNNIRNYYACMTGVDENIGRIINELKRLGL
FKNTIVVFTSDHGICMGAHEQAGKDIFYEESMRIPVLISWPEKIKPKTDRTTMIAFADLY
PTLLSIMGFQQQIPEEVQTFNLASVLLYGKENNRIVQPYYYIQSSNPATGYRGLRTATHT
FTIHATDGKVDKIILFDRRSNPYQMNNIAMQHPKLVNRLKSQLKTWLQKTEDPFFNYL