Protein Info for HMPREF1058_RS10130 in Phocaeicola vulgatus CL09T03C04

Annotation: MBL fold metallo-hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 244 PF00753: Lactamase_B" amino acids 13 to 61 (49 residues), 28 bits, see alignment 1e-10

Best Hits

KEGG orthology group: None (inferred from 44% identity to amt:Amet_2603)

Predicted SEED Role

"metallo-beta-lactamase domain protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9U878 at UniProt or InterPro

Protein Sequence (244 amino acids)

>HMPREF1058_RS10130 MBL fold metallo-hydrolase (Phocaeicola vulgatus CL09T03C04)
MGMELRVLGSSSSGNCYILDNGNEALIIEAGIRFIDVKKALDFNIRKVVGCLITHQHNDH
AKYAKAMVDCGFHVLALPEVIESKELKGSRVKAIKIGSGYLLGGFRVIPFPAFHDVPCVG
YFIKHPDCGSIMFLTDSCQSGYTFSGLNHILIECNYSDTKLIESINAGRVLPTQRNRLMV
SHMELESCKQALKENDLSNVANIVLLHLSSNNSDEHLFVSEVQKITGKAVYAAKPGLSIT
LNNF