Protein Info for HMPREF1058_RS09615 in Phocaeicola vulgatus CL09T03C04

Annotation: bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 PF00383: dCMP_cyt_deam_1" amino acids 1 to 103 (103 residues), 70.3 bits, see alignment E=1.7e-23 TIGR00326: riboflavin biosynthesis protein RibD" amino acids 9 to 316 (308 residues), 280.8 bits, see alignment E=8.1e-88 PF14437: MafB19-deam" amino acids 27 to 143 (117 residues), 51.4 bits, see alignment E=1.5e-17 PF01872: RibD_C" amino acids 150 to 315 (166 residues), 104.2 bits, see alignment E=1.2e-33

Best Hits

KEGG orthology group: K11752, diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC: 1.1.1.193 3.5.4.26] (inferred from 99% identity to bvu:BVU_0864)

Predicted SEED Role

"Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)" in subsystem Riboflavin, FMN and FAD metabolism (EC 1.1.1.193, EC 3.5.4.26)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.193 or 3.5.4.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I8ZSR3 at UniProt or InterPro

Protein Sequence (350 amino acids)

>HMPREF1058_RS09615 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD (Phocaeicola vulgatus CL09T03C04)
MTKDEKYISRCLQLAYNGLCNTAPNPMVGAVIVYHDTIIGEGYHIRCGEAHAEVNAIRSV
KDENLLKESTIYVSLEPCSHYGKTPPCADLIIEKRIPKVVIGCIDPFSQVAGRGIEKLRK
AGIEVTVGVLEEECRHLIRRFITFNTLKRPYITLKWAESADGFIDINRTGGKPIILSNPL
TSMLVHKKRAEHDAILVGRHTALLDNPSLSTRNWYGKHPVRLVIDKELTLPRDLELFNGK
IKTFVFTRESPCQPNALTEYISLDFNKDILPQIMEVLYQKKIQSLLVEGGSILLQSFIDS
GLWDEAFIEKAPLRLNNGIQAPSIQKKHFKLNKIYFGREIMHAVHSQIQR