Protein Info for HMPREF1058_RS08575 in Phocaeicola vulgatus CL09T03C04

Annotation: sulfatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 527 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF00884: Sulfatase" amino acids 37 to 412 (376 residues), 178.8 bits, see alignment E=2.5e-56 PF16347: SGSH_C" amino acids 360 to 513 (154 residues), 257 bits, see alignment E=1.1e-80

Best Hits

Swiss-Prot: 54% identical to GLCSF_BACTN: N-acetylglucosamine-6-O-sulfatase (BT_4656) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: None (inferred from 100% identity to bvu:BVU_0538)

Predicted SEED Role

"Mucin-desulfating sulfatase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9IVX6 at UniProt or InterPro

Protein Sequence (527 amino acids)

>HMPREF1058_RS08575 sulfatase (Phocaeicola vulgatus CL09T03C04)
MNNLQSGLLFSLTGITAVASLSSCASQKKTEEQKPYNIVYIMTDDHTAQMMSCYDKRYME
TPNLDRIANDGVRFTNSFVANSLSGPSRACMITGKHSCTNKFYDNTTCIFDGSQQTFPKL
LQQAGYQTALIGKWHLESLPTGFNYWEIVPGQGDYYNPDFITQDNDTIQKHGYITNIITD
DAIDWMENKRDKDKPFCILIHHKAIHRNWLADTCNLSLYEDKTFPLPDNFFDDYEGRPAA
AAQEMSIVKDMDMIYDLKMLRPDKQTRLKALYENYIGRMDEGQRAAWDKFYGPIIDDFYK
KNPQGKELADWKFQRYMRDYMKTVKSLDDNVGRVLDYLKEKNMLDNTLVVYTSDQGFYMG
EHGWFDKRFMYEESMHTPLIMRLPKGFDRKGDITELVQNIDYAPTFLELAGAPVPEDIQG
VSLLPLLKGEKPADWRKSLYYHFYEYPAEHMVKRHYGVRTERYKLIHFYNDIDVWELYDL
QADPTEMHNLYGQKEYEPVVTELKTELARLQEQYNDPVRFSPDRDKE