Protein Info for HMPREF1058_RS08310 in Phocaeicola vulgatus CL09T03C04

Annotation: TonB family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 297 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details TIGR01352: TonB family C-terminal domain" amino acids 224 to 297 (74 residues), 41.2 bits, see alignment E=8.1e-15 PF03544: TonB_C" amino acids 233 to 296 (64 residues), 24.7 bits, see alignment E=1.3e-09

Best Hits

KEGG orthology group: None (inferred from 100% identity to bvu:BVU_0474)

Predicted SEED Role

"Ferric siderophore transport system, periplasmic binding protein TonB" in subsystem Campylobacter Iron Metabolism or Hemin transport system or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9IW23 at UniProt or InterPro

Protein Sequence (297 amino acids)

>HMPREF1058_RS08310 TonB family protein (Phocaeicola vulgatus CL09T03C04)
MKKNKITGLIGTAVLHILLLILLLVIAIRRPQVQEEGGVPVMLGNTELSQGNADPYTLTD
IDIMNEPEAPAPDVSEPETVPPVEAKEEIITQTEEETVAVPKKEPKKETPKKEKPKKETP
KKDVPKKEAVKPKEKTEAEKRAEAEKAAAEKKAAAERAAAEAAAKKIAGAFGKGTQMGNK
GTGTTGSGLEGSPTGNSSEGKSGGVGGYGTFDLNGRSLGSGGLPMPVYNVQDEGRVVVTI
TVNPAGQVISTSINKRTNTVNASLRKAAEEAARKARFNQVDGVNNQTGTITYYFKLK