Protein Info for HMPREF1058_RS07755 in Phocaeicola vulgatus CL09T03C04

Annotation: TolC family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 495 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF02321: OEP" amino acids 129 to 264 (136 residues), 40.9 bits, see alignment E=9.7e-15 amino acids 287 to 473 (187 residues), 80.9 bits, see alignment E=5.6e-27

Best Hits

KEGG orthology group: None (inferred from 100% identity to bvu:BVU_0059)

Predicted SEED Role

"outer membrane protein TolC, putative"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9U672 at UniProt or InterPro

Protein Sequence (495 amino acids)

>HMPREF1058_RS07755 TolC family protein (Phocaeicola vulgatus CL09T03C04)
MKYISIWMVGCMLLSFGAKAQQVVKLDLQRTIEIANDSSLSAFRYQNLYLSGYWEYRTYK
ANRLPSLTLDLTPAKYYRYITQRYDSNEDMDVYREQQMFSASGGLSIKQNLDWTGGTFYI
DSELDFMRNFGDSKSTQYSSIPVRVGYQQSLLGYNAFRWDRKIEPLKYEKVKKQFIYNTE
MVSEEAVTYFFALAMAQADYRLAEENVASSDTLYSIGLQRHKIAAISRADLLTLQLDKVN
AHNTLQNAQIALKRAMFSLASFLNLDKNTLIELDIPGRPTGKMIPVDDALMRAKENNPTF
LEQRQNVLEAEQNVDKTKKESRFNASFNASVGFNQVADKLGDAYRHPLQQDLVSVSVSIP
LIDWGVRKGKYNMARNNLNVVRIAARQEELSVEEEVIMTVNDFNIQQSLIASAEEALDLA
VMAYEQTRQRFIIGKADVNSLTLSLNRQQEAQKNYISALQNYWLNYYKIRKLTLHDFESG
FSLADKFDFNTGIYR