Protein Info for HMPREF1058_RS07395 in Phocaeicola vulgatus CL09T03C04

Annotation: family 20 glycosylhydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 774 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF02838: Glyco_hydro_20b" amino acids 29 to 156 (128 residues), 91.7 bits, see alignment E=1.5e-29 PF00728: Glyco_hydro_20" amino acids 159 to 508 (350 residues), 420.2 bits, see alignment E=1.9e-129 PF13290: CHB_HEX_C_1" amino acids 554 to 611 (58 residues), 57.7 bits, see alignment 2.4e-19 PF13287: Fn3_assoc" amino acids 558 to 614 (57 residues), 62.6 bits, see alignment 7.6e-21 PF00754: F5_F8_type_C" amino acids 641 to 752 (112 residues), 49.9 bits, see alignment E=8.9e-17

Best Hits

KEGG orthology group: K12373, hexosaminidase [EC: 3.2.1.52] (inferred from 100% identity to bvu:BVU_4138)

Predicted SEED Role

"Beta-hexosaminidase (EC 3.2.1.52)" in subsystem Chitin and N-acetylglucosamine utilization or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 3.2.1.52)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.52

Use Curated BLAST to search for 3.2.1.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9U3W4 at UniProt or InterPro

Protein Sequence (774 amino acids)

>HMPREF1058_RS07395 family 20 glycosylhydrolase (Phocaeicola vulgatus CL09T03C04)
MKTLMGLAGLTMAGFMLLSCDTEVKEANYQIIPLPQEISVMDQAAPFILSNGTKIMYPEG
NEKMQKNAEFLASYIKDLTGKSLAVQAGTDGKGIILQLGGNAENPEGYQLKVTSDQVVIS
GPTEAGVFYGIQTLRKSIPVAQGVDIALPAVEINDYPRFSYRGAMLDVSRHFFPVDSVKR
FIDMLALHNINRFHWHLSEDQGWRIEIKSRPELTEIGSKRAETVIGHNSGKYDGKPYGGF
FTQEEAKEIVAYAAERHITVIPEIDMPGHMQAALAAYPNLGCTGGPYEVWKIWGVSEDVL
CAGNDETLKFIEDVLGEIIQIFPSEYIHVGGDECPKVRWAKCPKCQARIKALGLKSDKNH
TAEERLQSFIINHAEKFLNGHGRQIIGWDEILEGGLAPNATVMSWRGVAGGIEAAKQKHD
VIMTPNTYLYFDYYQTKDIANEPEAIGGYVPVETVYNYEPMPADLTPEEQKYIIGVQANL
WTEYIPTYSQVEYMELPRMAALSEIQWTMPEKKNYEGFLKRLPQLVDIYDVYKYNYAKHV
FDVNAVFTPNPKDGTLDVTLSTIDNSPIYYTLDGTEPSAASQLYTETLKLKQNCTFKAIT
VRPAGNSRVVTEEIAFNKASMKPVTMLQPVNKQYEFKGAPTLVDGLKGNGNYKTGRWIAF
YKNDMEAVIDMQQPTEISSASISTCVEKGDWVFDARAFSVAVSEDGKNFKEIASEKYPAM
KQDDKNGVFNHTLTFDPVTARYVKVTALAEHSIPAWHGGKGNPAFLFVDEISLN