Protein Info for HMPREF1058_RS07385 in Phocaeicola vulgatus CL09T03C04

Annotation: family 20 glycosylhydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 684 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details PF02838: Glyco_hydro_20b" amino acids 27 to 144 (118 residues), 75.8 bits, see alignment E=7.7e-25 PF00728: Glyco_hydro_20" amino acids 148 to 490 (343 residues), 404.3 bits, see alignment E=7.9e-125 PF00754: F5_F8_type_C" amino acids 558 to 669 (112 residues), 33.5 bits, see alignment E=6.4e-12

Best Hits

KEGG orthology group: K12373, hexosaminidase [EC: 3.2.1.52] (inferred from 100% identity to bvu:BVU_4136)

Predicted SEED Role

"Beta-hexosaminidase (EC 3.2.1.52)" in subsystem Chitin and N-acetylglucosamine utilization or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 3.2.1.52)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.52

Use Curated BLAST to search for 3.2.1.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9U4R5 at UniProt or InterPro

Protein Sequence (684 amino acids)

>HMPREF1058_RS07385 family 20 glycosylhydrolase (Phocaeicola vulgatus CL09T03C04)
MRRLIILAEVALGLLFASCTKEEQRTLSVIPAPLKVELQQEVFSLNSETGLYIDASEGDK
KILEDYLVASSMNLKPVIAEEGHNVVLKQVAELPEVNSSEGYVLTVTPDQVLIRATSGAG
LFYGVQTMLQMVDEKGLPAGVITDEPRFAYRGFMMDVSRHFFDKEFIKKQMDALAYYKLN
RLHLHLTDAAGWRLEIKKYPRLTEFAAWREFPTWKEWWNNGRRYEEEGSKDAHGGYYTQD
DIRELVAYAQERFITVIPEIEMPAHSEEVLTAYPELSCTHEPYKQADFCVGNEKTFEFLE
NVLTEVMELFPSEYIHIGGDEAGKASWPTCKLCQARMKKEGLKDVNELQSYLIHRIEVFL
NAHGRKLLGWDEILEGGLAPNATVMSWRGTEGGMKAVDSGHMAIMSPGEFCYFDSYQDAP
DSQPEAIGGYLPLSKVYSFNPVPDTLSADKVQLVYGVQANLFTEYIPTPEHAEMMIYPRI
LALAEVAWSAPSVKNYDDFHVRALKEVEALKAEGYHPFDLKNEIGNRPGADQPVQHLAVG
KKVAYGPDAAYYPGYSAGGDSALVDGVIGGWTYGDRRWQGFIDKKRMDVTIDMEKETEIH
SVGADFMQVCGPEVFMPSEVIISVSNDGKEFTELKRMEHKVVKDDKVTFINFGWEGNAKA
RYIRYQASSGEFGGFLFTDEIVVK