Protein Info for HMPREF1058_RS07375 in Phocaeicola vulgatus CL09T03C04

Annotation: DUF4982 domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 834 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF02837: Glyco_hydro_2_N" amino acids 31 to 193 (163 residues), 56.5 bits, see alignment E=8.5e-19 PF00703: Glyco_hydro_2" amino acids 204 to 308 (105 residues), 75 bits, see alignment E=1.9e-24 PF02836: Glyco_hydro_2_C" amino acids 315 to 541 (227 residues), 85.3 bits, see alignment E=1.1e-27 PF16355: DUF4982" amino acids 636 to 715 (80 residues), 76.1 bits, see alignment E=4e-25 PF18565: Glyco_hydro2_C5" amino acids 728 to 828 (101 residues), 121 bits, see alignment E=4.6e-39

Best Hits

KEGG orthology group: K01190, beta-galactosidase [EC: 3.2.1.23] (inferred from 100% identity to bvu:BVU_4134)

Predicted SEED Role

"Beta-galactosidase (EC 3.2.1.23)" in subsystem Galactosylceramide and Sulfatide metabolism or Lactose and Galactose Uptake and Utilization or Lactose utilization (EC 3.2.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.23

Use Curated BLAST to search for 3.2.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I8ZMX3 at UniProt or InterPro

Protein Sequence (834 amino acids)

>HMPREF1058_RS07375 DUF4982 domain-containing protein (Phocaeicola vulgatus CL09T03C04)
MNTKRFLCAALGAVCYFAFLQAQVRTEQTFEKGWKFTREDNAEFANPGYNDSKWQNVTVP
HDWAIYGPFSINNDKQEMAITQDGQTEAMEHAGRTGGLPFVGTGWYRLNFDAPGFEKGKK
ATLIFDGAMSHARVYVNGQEAGYWPYGYNSFYVDATPYLKPGERNELAVRLENEPESSRW
YPGAGLYRNVHLVINEDTHIPAWGMYVTTPVVTDKYAKVSLKTSLVSPEGANKDNYRIVT
QIKDKNGKVVATGENKLSVFDNALFEQEFAVANPELWSPDTPVLYTAESKVYEGNTLKDE
YTTRFGIRTLEIVPGKGFFLNGKLTKFKGVCNHHDLGPLGGAVNDAAIRRQIRILKDMGC
NAIRTSHNMPAPELVEACDEMGMMLMVESFDEWKSAKMANGYHKIFDEWVEKDLTNLIRH
YRNNPSIVMWCIGNEVPDQWNGNNGPKLSRMLQDICHREDPTRPVTQGMDAPDAVVNNNM
AAVMDVAGFNYRPHKYPENYKKLPQQIILGSETASTVSSRGVYKFPVVRQAMKKYDDHQS
SSYDVEHCGWSNLPEDDWIWHEDNAWGIGEFVWTGFDYLGEPTPYYTDWPSHSSLFGIID
LAGLPKDRYYLYRSHWNKDEETLHILPHWTWPGREGEVTPIFVYTNYPSAEVFINGKSQG
KRTKDLTVTAENSADSASIADFKRQKRYRLMWMDTKYEPGTVKVVAYNEKGEAVAEKEIH
TAGKPDHIELVADRNEIKADGKDLSFVTVRVVDKEGNLCPDAQHLIKYSVKGAGTYRAGA
NGDPTSLELFHVPQMKVFNGMMTAVVQSTDKPGEIILTATGKGLKSGRLVLMSK