Protein Info for HMPREF1058_RS06840 in Phocaeicola vulgatus CL09T03C04

Annotation: HpaII family restriction endonuclease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

KEGG orthology group: K01155, type II restriction enzyme [EC: 3.1.21.4] (inferred from 100% identity to bvu:BVU_3992)

Predicted SEED Role

"Type II restriction enzyme HpaII (EC 3.1.21.4)" (EC 3.1.21.4)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.21.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9U456 at UniProt or InterPro

Protein Sequence (362 amino acids)

>HMPREF1058_RS06840 HpaII family restriction endonuclease (Phocaeicola vulgatus CL09T03C04)
MAFEATKREWGELYAFFRLLADGYVYAGTPDVKRNEVQKLPVAMVQREEHDGTRRYILED
EATVRICGEKIDKQIPREDFAAVAELVFAAVKESRENDVMSPDGVEEFLDEVAIYDLEAK
TDDRTDFYVAFYSIEAPLVGFCVRSRLGTMFPLLDGGRTANLKFEQTGVKFATPTVNKIN
AFGEEDDVAGRMLMIERLGGILKYNDVADKVFRSNLCMIDLHFPRMLGEMLRVMHLDGIS
KVSDLTEAIKQINPLKIKDELIHKHSYYEYKMKQFLMALALGMRPAKIFNGIDSAISGFL
FVNGNGEVLCYQKADRQVFADFLFVNSRFEKSSTEKDKYGYLERENGVYYFKLNLKIGLL
KR