Protein Info for HMPREF1058_RS06405 in Phocaeicola vulgatus CL09T03C04

Annotation: Na+/H+ antiporter NhaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 446 transmembrane" amino acids 21 to 40 (20 residues), see Phobius details amino acids 71 to 89 (19 residues), see Phobius details amino acids 108 to 129 (22 residues), see Phobius details amino acids 137 to 157 (21 residues), see Phobius details amino acids 167 to 188 (22 residues), see Phobius details amino acids 194 to 213 (20 residues), see Phobius details amino acids 220 to 248 (29 residues), see Phobius details amino acids 314 to 334 (21 residues), see Phobius details amino acids 345 to 368 (24 residues), see Phobius details amino acids 380 to 406 (27 residues), see Phobius details amino acids 418 to 439 (22 residues), see Phobius details PF06965: Na_H_antiport_1" amino acids 17 to 435 (419 residues), 460.3 bits, see alignment E=2.3e-142 TIGR00773: Na+/H+ antiporter NhaA" amino acids 22 to 435 (414 residues), 375.9 bits, see alignment E=1.1e-116

Best Hits

Swiss-Prot: 100% identical to NHAA_BACV8: Na(+)/H(+) antiporter NhaA (nhaA) from Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154)

KEGG orthology group: K03313, Na+:H+ antiporter, NhaA family (inferred from 100% identity to bvu:BVU_3904)

Predicted SEED Role

"Na+/H+ antiporter NhaA type" in subsystem Na(+) H(+) antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I8ZPV5 at UniProt or InterPro

Protein Sequence (446 amino acids)

>HMPREF1058_RS06405 Na+/H+ antiporter NhaA (Phocaeicola vulgatus CL09T03C04)
MEKLKILNLNFSFQRAAHYHINGGMLLMGVVLLAMFLANSPWGDIYASFWNYEVHLQIGE
FNFFSHNGHHMTLMTFINDALMAVFFFSVGLEIKREILVGELSSFRQALLPIVAACGGML
VPVLIYYFMTAGTPAQSGLAIPMATDIAFSLGVLSLFGKRVPLSLKVFLTAFAVVDDIGG
ILVIALFYTSHLSVNYLIASAGILLILCGGNFFRVRNRWFYIFWGVIMWYLFLQSGIHAT
IAGVVAAFTVPATPHYKIGKYINRIRENIAVFPASDKESVVLSKMQINVLKSIESSSDRV
ISPLQSLEDSLHGMVNYIILPLFAFANAGVSLTADHGGLEVGMATWAVLAGLLAGKFAGI
YFFTWLVIKMGFAGLLKGMTWVNLTGICLLGGIGFTVSLFIANLSFGDSPVLLTQAKMGV
ILGTVLAGVLAYLVLQFALPKQPAQE