Protein Info for HMPREF1058_RS05865 in Phocaeicola vulgatus CL09T03C04

Annotation: thioredoxin-disulfide reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 315 TIGR01292: thioredoxin-disulfide reductase" amino acids 7 to 309 (303 residues), 368.5 bits, see alignment E=9.5e-115 PF07992: Pyr_redox_2" amino acids 7 to 298 (292 residues), 156 bits, see alignment E=2.3e-49 PF13738: Pyr_redox_3" amino acids 57 to 281 (225 residues), 59.4 bits, see alignment E=5.6e-20 PF00070: Pyr_redox" amino acids 149 to 219 (71 residues), 47.3 bits, see alignment E=3.8e-16

Best Hits

Swiss-Prot: 50% identical to TRXB_RICBR: Thioredoxin reductase (trxB) from Rickettsia bellii (strain RML369-C)

KEGG orthology group: K00384, thioredoxin reductase (NADPH) [EC: 1.8.1.9] (inferred from 100% identity to bvu:BVU_3628)

Predicted SEED Role

"Thioredoxin reductase (EC 1.8.1.9)" in subsystem Glycine reductase, sarcosine reductase and betaine reductase or Thioredoxin-disulfide reductase or Wyeosine-MimG Biosynthesis (EC 1.8.1.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9U3E0 at UniProt or InterPro

Protein Sequence (315 amino acids)

>HMPREF1058_RS05865 thioredoxin-disulfide reductase (Phocaeicola vulgatus CL09T03C04)
MSTEKVKCLIIGSGPAGYTAAIYTGRANIAPVLYEGLQPGGQLTITTEVENFPGYPEGIS
GTQLMEDLRKQAERFGADIRNGIATSADLSKRPYRITIDDEKVIEAETVIISTGATAKYL
GLEDEQKYAGMGVSACATCDGFFYRKKTVAVVGGGDTACEEAVYLAGLAKQVYLIVRKPF
LRASKIMQARVMNHPNIKVLFEHNAVGLYGENGVEGVHLVKRQGECNEERYDLPIDGFFL
AIGHKPNSDIFKDYLDTDEVGYIITEAGTPRTKVPGVFAAGDVADPHYRQAITAAGSGCK
AAIEAERYLSANDLL