Protein Info for HMPREF1058_RS05040 in Phocaeicola vulgatus CL09T03C04

Annotation: phospho-sugar mutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02878: PGM_PMM_I
  • amino acids 51 to 190 (140 residues), 135 bits, E=3e-43
• PF02879: PGM_PMM_II
  • amino acids 214 to 318 (105 residues), 90.9 bits, E=1.4e-29
• PF02880: PGM_PMM_III
  • amino acids 328 to 450 (123 residues), 68.7 bits, E=9.8e-23
• PF00408: PGM_PMM_IV
  • amino acids 506 to 562 (57 residues), 28.9 bits, 2e-10

Best Hits

Swiss-Prot: 42% identical to PGCA_BACSU: Phosphoglucomutase (pgcA) from Bacillus subtilis (strain 168)

KEGG orthology group: K01840, phosphomannomutase [EC: 5.4.2.8] (inferred from 100% identity to bvu:BVU_3804)

MetaCyc: 42% identical to alpha-phosphoglucomutase (Bacillus subtilis)
Phosphoglucomutase. [EC: 5.4.2.2]

Predicted SEED Role

"Phosphoglucomutase (EC 5.4.2.2)" (EC 5.4.2.2)

MetaCyc Pathways

• dTDP-β-L-rhamnose biosynthesis (5/5 steps found)
• glycogen degradation I (7/8 steps found)
• O-antigen building blocks biosynthesis (E. coli) (9/11 steps found)
• colanic acid building blocks biosynthesis (9/11 steps found)
• D-galactose degradation I (Leloir pathway) (4/5 steps found)
• superpathway of anaerobic sucrose degradation (14/19 steps found)
• GDP-mannose biosynthesis (3/4 steps found)
• glycogen biosynthesis I (from ADP-D-Glucose) (3/4 steps found)
• starch degradation V (3/4 steps found)
• sucrose degradation IV (sucrose phosphorylase) (3/4 steps found)
• β-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation (2/3 steps found)
• GDP-α-D-glucose biosynthesis (2/3 steps found)
• trehalose degradation V (2/3 steps found)
• glycogen degradation II (4/6 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• UDP-α-D-glucose biosynthesis (1/2 steps found)
• sucrose biosynthesis I (from photosynthesis) (6/9 steps found)
• glucose and glucose-1-phosphate degradation (3/5 steps found)
• sucrose degradation II (sucrose synthase) (3/5 steps found)
• sucrose biosynthesis II (5/8 steps found)
• starch degradation III (2/4 steps found)
• β-(1,4)-mannan degradation (4/7 steps found)
• glucosylglycerol biosynthesis (2/5 steps found)
• superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis (8/14 steps found)
• starch biosynthesis (5/10 steps found)
• chitin biosynthesis (4/9 steps found)
• CDP-6-deoxy-D-gulose biosynthesis (1/5 steps found)
• glycogen biosynthesis III (from α-maltose 1-phosphate) (3/8 steps found)
• superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (5/19 steps found)
• streptomycin biosynthesis (1/18 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (11/33 steps found)

KEGG Metabolic Maps

• Fructose and mannose metabolism
• Galactose metabolism
• Glycolysis / Gluconeogenesis
• Nucleotide sugars metabolism
• Pentose phosphate pathway
• Starch and sucrose metabolism
• Streptomycin biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 5.4.2.8

Use Curated BLAST to search for 5.4.2.2 or 5.4.2.8

Sequence Analysis Tools

See I8ZJ88 at UniProt or InterPro

Protein Sequence (581 amino acids)

>HMPREF1058_RS05040 phospho-sugar mutase (Phocaeicola vulgatus CL09T03C04)
MENEELIKQVTEKAEKWLTPAYDAETQAEIKQMLANPDKTDLIEAFYKDLEFGTGGLRGI
MGVGSNRMNIYTVGAATQGLSNYLNKNFKDLDQISVVVGHDCRNNSRLFAEISANIFSAN
GIKVYLFEDMRPTPEMSFAIRHFGCQSGINITASHNPREYNGYKAYWDDGAQVLAPHDKG
IIDEVNKISSATDIKFEGNKDLIQIVGEEVDSVYLNKVKTISIDPEVIKRQKDLKIVYTP
IHGTGMMLIPRALKQWGFENVHTVPEQMVKSGDFPTVVSPNPENAEALSMAIDLAKKIDA
DIVMASDPDADRVGMACKNDKGEWVLINGNQTCLLFLYYIIKNRIAMGKMKDDDFIVKTI
VTTELIKSVADKNHIEMLDCYTGFKWIAREIRLREGKQQYIGGGEESYGFLAEDFVRDKD
AVSACTLLAEICAWAKDQGKTLFEVLLDIYVEYGFSKETTVNVVKPGKSGAEEIKAMMEN
FRSNPPREIGGSKVVLVKDFKTLKVTDGNGNITEIDMPEASNVLQYFTEDGTKISVRPSG
TEPKIKFYVEVKGEMGCHKCFDAANAAAEEKVEAVRKSLGI