Protein Info for HMPREF1058_RS04690 in Phocaeicola vulgatus CL09T03C04

Annotation: cation:proton antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 755 transmembrane" amino acids 6 to 25 (20 residues), see Phobius details amino acids 32 to 50 (19 residues), see Phobius details amino acids 60 to 79 (20 residues), see Phobius details amino acids 90 to 113 (24 residues), see Phobius details amino acids 120 to 138 (19 residues), see Phobius details amino acids 150 to 172 (23 residues), see Phobius details amino acids 187 to 210 (24 residues), see Phobius details amino acids 222 to 255 (34 residues), see Phobius details amino acids 295 to 320 (26 residues), see Phobius details amino acids 332 to 352 (21 residues), see Phobius details amino acids 358 to 382 (25 residues), see Phobius details amino acids 423 to 449 (27 residues), see Phobius details amino acids 455 to 478 (24 residues), see Phobius details amino acids 499 to 520 (22 residues), see Phobius details amino acids 526 to 548 (23 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 16 to 377 (362 residues), 195.2 bits, see alignment E=1.6e-61 PF02080: TrkA_C" amino acids 593 to 659 (67 residues), 54.6 bits, see alignment E=8.3e-19 amino acids 682 to 746 (65 residues), 39.8 bits, see alignment E=3.6e-14

Best Hits

KEGG orthology group: K03455, monovalent cation:H+ antiporter-2, CPA2 family (inferred from 100% identity to bvu:BVU_3827)

Predicted SEED Role

"POTASSIUM/PROTON ANTIPORTER ROSB" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I8ZL05 at UniProt or InterPro

Protein Sequence (755 amino acids)

>HMPREF1058_RS04690 cation:proton antiporter (Phocaeicola vulgatus CL09T03C04)
MSELAPLISDLALILICAGVMTLVFKRLKQPLVLGYIVAGFLASPHVPLTPSVIDVANIH
TWSEIGVIFLLFALGLEFSFKKLVKVGGTAVIAACTIIFCMILVGIFVGWSFGWQRMDCL
YLGGMLAMSSTTIIYKAFDDLGLRQQRFAGLVLSILILEDILAIVLMVMLSTMAVSQNFE
GSEMVYSIAKLLFFLILWFVVGIYIIPTFLKRSRKWMANETLLIVSLALCFGMVVVAAKV
GFSAAFGAFIMGSILAETVEAENIEKLVAPVKDLFGAIFFVSVGMMVDPAMIVEYIWPIV
IITLAILLGQVIFGTGGVILSGQPLKVAMQCGFSLTQIGEFAFIIASLGVSLKVTSDFLY
PIVVAVSVITTFLTPYMIRLAIPAYHIVEKRLPGKWKKMLERYSSGSQTVNHENNWKKLL
VAIARIVAVYSVLCIAMITLSFHFIIPLFRASLPVFWANLAGTVFTIVCIAPFLRAIIMK
KNHSVEFQALWQDSRFNRAPLISTILLRIVIAVMFVMFVIEKLFQTSTTLLIGIAVVLVG
MMMFSRWLKKQSIFMERTFIQNLRFRDVHAEFTGQKRPEYEGHLLSRDLHLSDFEIPADS
LWAGYTLRELNLGHKYGVHVASIIRGMHRINIPGANVRLFPGDTIQVIGTDEQLGEFARQ
AERVSAAAEEEDLERREMNLKQFIIDRNSFFLGKNIKESGIRDEYKCLVVGVEKEDSTLM
TPDINVPFTEGDVVWVVGERDDVYRLLGKKEKEEE