Protein Info for HMPREF1058_RS04225 in Phocaeicola vulgatus CL09T03C04

Annotation: helix-turn-helix transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 296 transmembrane" amino acids 252 to 276 (25 residues), see Phobius details PF02311: AraC_binding" amino acids 39 to 164 (126 residues), 23 bits, see alignment E=8.6e-09 PF12833: HTH_18" amino acids 214 to 292 (79 residues), 67.6 bits, see alignment E=1.5e-22 PF00165: HTH_AraC" amino acids 256 to 292 (37 residues), 28.1 bits, see alignment 2.6e-10

Best Hits

KEGG orthology group: None (inferred from 67% identity to bth:BT_1385)

Predicted SEED Role

"transcriptional regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9TZT4 at UniProt or InterPro

Protein Sequence (296 amino acids)

>HMPREF1058_RS04225 helix-turn-helix transcriptional regulator (Phocaeicola vulgatus CL09T03C04)
MKSSIPLYTFYKNKYGSELLIDIVALKDIKKYLAGKAVHTLTYYDITFITEGEGRFVIGH
QTYNAVSRDVFFSRPGEIRSWEINCIKNGYALIFEDEFLSSFFKDTQFVQHLSYFHPGET
SLKLQLPEELYIRMLQLLQHIKKEIDTYQPGNVHMLRALLYEALMLLDRCYQKTLSAIGN
ETLTGSKENNSPYIERFIKLVEENLKEQHSVQFYADCLCITSNYLNELVHSVLYTSAKQY
IRNKVMNEARKLLAYTDIPVSEIALILHFSTVSYFIRSFRQHTGKTPFNYRREQQP