Protein Info for HMPREF1058_RS04010 in Phocaeicola vulgatus CL09T03C04

Annotation: molecular chaperone HtpG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 681 PF13589: HATPase_c_3" amino acids 27 to 144 (118 residues), 35.4 bits, see alignment E=1.5e-12 PF02518: HATPase_c" amino acids 29 to 127 (99 residues), 26.8 bits, see alignment E=9.1e-10 PF00183: HSP90" amino acids 210 to 580 (371 residues), 159.5 bits, see alignment E=2.4e-50

Best Hits

Swiss-Prot: 82% identical to HTPG_BACFR: Chaperone protein htpG (htpG) from Bacteroides fragilis (strain YCH46)

KEGG orthology group: K04079, molecular chaperone HtpG (inferred from 100% identity to bvu:BVU_3300)

Predicted SEED Role

"Chaperone protein HtpG" in subsystem Protein chaperones

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9IP90 at UniProt or InterPro

Protein Sequence (681 amino acids)

>HMPREF1058_RS04010 molecular chaperone HtpG (Phocaeicola vulgatus CL09T03C04)
MQKGNIGVTTENIFPIIKKFLYSDHEIFLRELVSNAVDATQKLKTLASKGEFKGEMGDLT
IKVSLGKDTITISDRGIGLTAEEIDKYINQIAFSGANDFLEKYKDDANAIIGHFGLGFYS
AFMVAKKVEIITKSHQEGAQAVKWTCDGSPEFTIENVEKESRGSDIILYIDDDCKEFLEE
TRISSLLTKYCRFLPIPIAFGKKKEWKDGKQVETNEDNVINETYPLWTRKPVELKDEDYK
KFYRELYPMADEPLFWIHLNVDYPFNLTGILYFPKVKSNIELQKNKIQLYCNQVYVTDSV
EGIVPDFLTLLHGVIDSPDIPLNVSRSYLQSDSNVKKISTYISKKVSDRLQAIFKNDRKE
FEEKWDDLKIFINYGMLTQEDFYEKANKFALLKDTDDKYYTYEEYQSLIKDNQTDKDGNL
IYLYATHADEQYSYIDAAKNKGYNVLLMDGQLDVAMVSMLEQKFEKSRFTRVDSDVIDHL
IAKEERKDASLEVGQRDILSSVFRSQLPQMKKVEFNVETQSLGETGTPIMITQSEYMRRM
KEMANIQAGMSFYGEMPDMFNLVLNVDHKLVKQVLNDADNSCKAALEPIEAEMTSLNKRH
DELHKAQEGKKADEIPQAEKDELSDVEKKLADEKTKKEAVLGEYAGGNKVIRQLIDLALL
QNNMLKGEALTNFVKRSIELI