Protein Info for HMPREF1058_RS03355 in Phocaeicola vulgatus CL09T03C04

Annotation: efflux RND transporter periplasmic adaptor subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 416 transmembrane" amino acids 16 to 34 (19 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 211 to 411 (201 residues), 97.3 bits, see alignment E=4.2e-32 PF13437: HlyD_3" amino acids 233 to 329 (97 residues), 43.2 bits, see alignment E=8.5e-15

Best Hits

KEGG orthology group: K02005, HlyD family secretion protein (inferred from 100% identity to bvu:BVU_3525)

Predicted SEED Role

"ABC transporter permease"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9TYQ4 at UniProt or InterPro

Protein Sequence (416 amino acids)

>HMPREF1058_RS03355 efflux RND transporter periplasmic adaptor subunit (Phocaeicola vulgatus CL09T03C04)
MDTLIERKKRFTPRRIYGGAGVLFILVFVFYFIFRDTGSSMTIDKSRITIATVTENEFND
YVRVIGQVLPSRMIYLDAIEGGRVEERLHEEGAMVKKGDVILRLSNPLLNIGIMQSEADL
AYQENELRNTRISMEQERLSLKQDRIGIQKEFIIKKRRYGQYKRLMEGQLIAREDYLQAT
EEYEAVKEQLSVLDERIRQDSLFRLTQISSLDENIMNMKRSLALVRERLENLKVKAPIDG
QVGNLEAQIGQSISAGEHIGQIITADLKVQALIDEHYVERVVQELPADFTRDGENYKLEV
TKVYPEVKDGQFRTDFRFTTGRPENIRAGQTYHINLQLGDPVKAVLIPRGGFFQITGGRW
IYVVDESGKFAVRRPIKIGRQNPQFYEVTDGLASGEKVIISGYELFGDNEKLILNE