Protein Info for HMPREF1058_RS03240 in Phocaeicola vulgatus CL09T03C04

Annotation: ribose-phosphate pyrophosphokinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 312 TIGR01251: ribose-phosphate diphosphokinase" amino acids 8 to 308 (301 residues), 356.7 bits, see alignment E=4.1e-111 PF13793: Pribosyltran_N" amino acids 8 to 122 (115 residues), 158 bits, see alignment E=1.3e-50 PF00156: Pribosyltran" amino acids 158 to 259 (102 residues), 58.8 bits, see alignment E=6.1e-20 PF14572: Pribosyl_synth" amino acids 198 to 308 (111 residues), 91.2 bits, see alignment E=1.3e-29

Best Hits

Swiss-Prot: 76% identical to KPRS_PORGI: Ribose-phosphate pyrophosphokinase (prs) from Porphyromonas gingivalis (strain ATCC BAA-308 / W83)

KEGG orthology group: K00948, ribose-phosphate pyrophosphokinase [EC: 2.7.6.1] (inferred from 100% identity to bvu:BVU_3551)

MetaCyc: 46% identical to ribose-phosphate diphosphokinase (Escherichia coli K-12 substr. MG1655)
Ribose-phosphate diphosphokinase. [EC: 2.7.6.1]

Predicted SEED Role

"Ribose-phosphate pyrophosphokinase (EC 2.7.6.1)" in subsystem De Novo Purine Biosynthesis or Pentose phosphate pathway (EC 2.7.6.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.6.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9TYS0 at UniProt or InterPro

Protein Sequence (312 amino acids)

>HMPREF1058_RS03240 ribose-phosphate pyrophosphokinase (Phocaeicola vulgatus CL09T03C04)
MSKTSPFRVFSGTNSRYLAEKICNSLGCKLGNMNIMHFADGEFAVSYEESIRGAHVFLVQ
STFPNSDNLMELLLMIDAAKRASAKSIVAVIPYFGWARQDRKDKPRVSIGAKLVADLLSV
AGIDRLITMDLHADQIQGFFDVPVDHLYASGVFLPYIESLQLEDLVIATPDVGGSKRAST
YSKYLGVPLVLCNKTRLKANEVATMQIIGDVKNKNVILIDDMVDTAGTITKAADIMKEAG
AISVRAIASHCVMSGPASERVQNSGLEEMVFTDSIPYANRCSKVKQLTIADMFAETIRRV
MNNESISSQYII