Protein Info for HMPREF1058_RS03075 in Phocaeicola vulgatus CL09T03C04

Annotation: DNA helicase RecQ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 726 TIGR01389: ATP-dependent DNA helicase RecQ" amino acids 9 to 601 (593 residues), 687.3 bits, see alignment E=1.7e-210 TIGR00614: ATP-dependent DNA helicase, RecQ family" amino acids 10 to 459 (450 residues), 511.9 bits, see alignment E=1.7e-157 PF00270: DEAD" amino acids 23 to 185 (163 residues), 86.4 bits, see alignment E=6.5e-28 PF04851: ResIII" amino acids 24 to 181 (158 residues), 24.4 bits, see alignment E=8.7e-09 PF00271: Helicase_C" amino acids 224 to 329 (106 residues), 76.9 bits, see alignment E=5.1e-25 PF16124: RecQ_Zn_bind" amino acids 341 to 402 (62 residues), 63.2 bits, see alignment 1.1e-20 PF09382: RQC" amino acids 405 to 514 (110 residues), 91.8 bits, see alignment E=9.4e-30 PF00570: HRDC" amino acids 535 to 597 (63 residues), 64.9 bits, see alignment E=1.8e-21 PF21220: RecQ-1-like_HTH" amino acids 623 to 673 (51 residues), 96.4 bits, see alignment 2.9e-31

Best Hits

KEGG orthology group: K03654, ATP-dependent DNA helicase RecQ [EC: 3.6.4.12] (inferred from 100% identity to bvu:BVU_0442)

Predicted SEED Role

"ATP-dependent DNA helicase RecQ" in subsystem DNA-replication or DNA repair, bacterial RecFOR pathway

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.12

Use Curated BLAST to search for 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9ILU6 at UniProt or InterPro

Protein Sequence (726 amino acids)

>HMPREF1058_RS03075 DNA helicase RecQ (Phocaeicola vulgatus CL09T03C04)
MTENINLTDALKKYFGFDTFKGNQEAIIRNLLAGNDTFVLMPTGGGKSLCYQLPSLIMDG
TAIVISPLIALMKNQVDAMRNFSEEDGVAHFINSSLNKSAIDQVKSDILSGKTKLLYVAP
ESLTKEENVDFLKGVKISFYAVDEAHCISEWGHDFRPEYRRIRPIINEIGKAPVIALTAT
ATPKVRMDIQKNLGMQDAQEFKSSFNRPNLYYEVRSKTNNIDRDIIKFIKANPGKSGIIY
CLSRKKVEELAEVLQANGINARAYHAGMDSATRTANQDGFLKEDIDVIVATIAFGMGIDK
PDVRFVIHYDIPKSLEGYYQETGRAGRDGGEGQCITFYSNKDLQKLEKFMQGKPVAEQEI
GKQLLLETAAYAESSICRRKSLLHYFGEEYTEENCGNCDNCLNPKKQVEAQDSLCAVIEA
IIAVKENFKADYIIDILLGKETSEVLAHKHEELEVFGSGMGEEEKMWNAVIRQALIAGYL
SKDVENYGLLKVTPEGHKFLKKPKSFKIVEDNDFEEEEEETPVRGGASCAVDPVLYSMLK
DLRKKLSKKLDVPPYVIFQDPSLEAMATIYPVTLEELQNIPGVGAGKAKRYGQEFCVLIK
KHCEENEIERPEDLRVRTVANKSKLKVSIIQAIDRKVALDDIAVSKGLEFGELLDEVEAI
VYSGTKLNIDYFLEEIMDEDHLNDIYDYFKESTTDKIDDAMDELGDDYTEDEIRLVRIKF
ISEMAN