Protein Info for HMPREF1058_RS03000 in Phocaeicola vulgatus CL09T03C04

Annotation: IMP dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00478: IMPDH
  • amino acids 12 to 476 (465 residues), 531.6 bits, E=1.6e-163
• TIGR01302: inosine-5'-monophosphate dehydrogenase
  • amino acids 12 to 458 (447 residues), 634.7 bits, E=4.5e-195
• PF00571: CBS
  • amino acids 97 to 144 (48 residues), 49 bits, 1.3e-16
  • amino acids 154 to 207 (54 residues), 48.7 bits, 1.6e-16

Best Hits

Swiss-Prot: 61% identical to IMDH_BACHD: Inosine-5'-monophosphate dehydrogenase (guaB) from Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)

KEGG orthology group: K00088, IMP dehydrogenase [EC: 1.1.1.205] (inferred from 100% identity to bvu:BVU_0428)

MetaCyc: 54% identical to inosine 5'-monophosphate dehydrogenase (Escherichia coli K-12 substr. MG1655)
IMP dehydrogenase. [EC: 1.1.1.205]

Predicted SEED Role

"Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)" in subsystem Purine conversions (EC 1.1.1.205)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• superpathway of purine nucleotide salvage (13/14 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis II (7/8 steps found)
• guanosine ribonucleotides de novo biosynthesis (4/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• purine nucleotides degradation II (aerobic) (8/11 steps found)
• ureide biosynthesis (3/7 steps found)
• adenosine nucleotides degradation I (3/8 steps found)
• purine nucleotides degradation I (plants) (5/12 steps found)
• superpathway of purines degradation in plants (5/18 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Drug metabolism - other enzymes
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.205

Sequence Analysis Tools

See I8ZHG1 at UniProt or InterPro

Protein Sequence (491 amino acids)

>HMPREF1058_RS03000 IMP dehydrogenase (Phocaeicola vulgatus CL09T03C04)
MSFIADKIVMDGLTYDDVLLIPAYSEVLPKTVELTTKFSRNIELKVPFVTAAMDTVTEAK
MAIAIAREGGIGVIHKNMSIEEQARQVAIVKRAENGMIYDPVTIKRGSTVRDALALMSEY
RIGGIPVVDDERYLVGIVTNRDLRFEKDMDKRIDEVMTKENIVTTNQSTDMEAASRILQE
HKIEKLPVVDKEGKLVGLITYKDITKAKDKPMACKDAKGRLRVAAGVGVTADTLDRMQAL
VDAGADAIVIDTAHGHSMYVIEKLKEAKKRFPNIDIVVGNIATGEAAKMLVEAGADGVKV
GIGPGSICTTRVVAGVGVPQLSAVYDVAKALKGTGIPLIADGGLRYSGDVVKALAAGGYS
VMIGSLVAGTEESPGDTIIFNGRKFKSYRGMGSLEAMENGSKDRYFQSGTADVKKLVPEG
IAARVPYKGTLYEVIYQLVGGLRAGMGYCGAANIEQLHDAKFTRITNAGVLESHPHDVAI
TSEAPNYSRPQ