Protein Info for HMPREF1058_RS02780 in Phocaeicola vulgatus CL09T03C04

Annotation: sigma-54-dependent Fis family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 460 PF00072: Response_reg" amino acids 5 to 115 (111 residues), 104.2 bits, see alignment E=1.4e-33 PF00158: Sigma54_activat" amino acids 157 to 322 (166 residues), 224.2 bits, see alignment E=2.4e-70 PF14532: Sigma54_activ_2" amino acids 158 to 327 (170 residues), 75.4 bits, see alignment E=1.6e-24 PF07728: AAA_5" amino acids 180 to 299 (120 residues), 31.4 bits, see alignment E=5.2e-11 PF02954: HTH_8" amino acids 418 to 456 (39 residues), 48 bits, see alignment 2.5e-16

Best Hits

KEGG orthology group: K07713, two-component system, NtrC family, response regulator HydG (inferred from 100% identity to bvu:BVU_0381)

Predicted SEED Role

"RteB, two-component system response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I8ZG38 at UniProt or InterPro

Protein Sequence (460 amino acids)

>HMPREF1058_RS02780 sigma-54-dependent Fis family transcriptional regulator (Phocaeicola vulgatus CL09T03C04)
MPHSILIVEDDLTFATMLKTWLGKKGFSVDTASSNARARKQLDAQPYDLVLSDLRLPDQD
GIFLLSWMKEQKYNIPLIIMTGYADIQSAVQAIKHGASDYISKPIQPDELLKKINEALQN
KALPTPVGIEKNTVAPKASKNKAVPHSATVPPSNFLEGESEAARQLYNYVGLVAPTPMSV
LINGASGTGKEYVAHRIHQLSKRADKPFIAIDCGSIPKELAASEFFGHVKGSFTGALNDK
TGAFVEANGGTLFLDEIGNLSYEVQIQLLRALQERRIRPVGSNKEIEVDVRLVSATNENL
QQAIEKGNFREDLYHRINEFTLRMPALKERQEDILLFANFFLDQANRELDRQLIGFDTAA
SQALQTYSWPGNLRQLKNIVKRATLLAQSNFITLAELGYELQEPIRSAGPQTFSLHDEAA
EKKRILEALKQTGNNKSKAAILLGIDRKTLYNKLKLYDIQ