Protein Info for HMPREF1058_RS02730 in Phocaeicola vulgatus CL09T03C04

Annotation: response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1440 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 877 to 899 (23 residues), see Phobius details PF07494: Reg_prop" amino acids 530 to 552 (23 residues), 22.3 bits, see alignment (E = 3.4e-08) PF07495: Y_Y_Y" amino acids 804 to 866 (63 residues), 46.3 bits, see alignment (E = 1.1e-15) PF00512: HisKA" amino acids 920 to 978 (59 residues), 46.9 bits, see alignment (E = 8.3e-16) PF02518: HATPase_c" amino acids 1026 to 1133 (108 residues), 82.6 bits, see alignment 9.7e-27 PF00072: Response_reg" amino acids 1185 to 1295 (111 residues), 88 bits, see alignment 1.7e-28 PF12833: HTH_18" amino acids 1361 to 1438 (78 residues), 70.4 bits, see alignment 4.7e-23

Best Hits

KEGG orthology group: None (inferred from 99% identity to bvu:BVU_0363)

Predicted SEED Role

"two-component system sensor histidine kinase/response regulator, hybrid ('one-component system')"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I8ZG46 at UniProt or InterPro

Protein Sequence (1440 amino acids)

>HMPREF1058_RS02730 response regulator (Phocaeicola vulgatus CL09T03C04)
MRNTIKLKYIWCTLFLLLHWGFVKAQPICVARQYTVRDGLIQSNPAQILQSHNGFIWVST
WNGVSRFDGRDFETFQFDSLLNQHMQRLENTADGNLWMIAYDRHSLYLYDIRENKLINVL
KQYEQHFNTPLQIENLYPLSKGITWVTLNNGGCFRISDKECTVSSGIQYITAIDDVELGK
VSRVFEDKQGEEWVFSDKGVSIFGKRIISSYPFSMFETMDNLVFLASQNGRLAYYDVNTM
QFNIVPFQEKIQHINGIKVLKDNQLAVLSDKGLYLCRFPELAMEKYDFSLPGRDDAAVRK
VYQDSKGFLWIFTGLPGIIRLDPETGVKQYLNTPSGYMASSPENELFIYEDPNGVVWTIP
YKGIFSYYDEKSRELKVYFTPGRNHIPYSPIIKTTYVDKQNNLWIKSQRSFIKMFFPPSP
YTYRELDNYFDTKSFLFDSDEHLWIATKKGIIRIMDSQKNLLGYLSPDGELAQTETVFAE
GGIYVMLKDQAQTIWLGSKENGLFRLVPRNRPYHYEVYHYMNNPSDPYSISDNKISCIDE
DHNGRIWIGTYGGGLNLVEEKEDGAIRFIHAENKLSGFPINRTNSIRCMVEGPGHTMLVG
TIEGLITFSSDFSDYENIRFYLNLPRPQVADGLCSADVMSVLRATDETIYCYCYGGGLCK
LVSSNLLSDELRFRSFGKETSPLARALIEDKNHNIWIGSETDITLFDVHDQTFESFGETF
FNRSFNYSECLPVTDRQGDILMGTEGGMLVFSPDSIVKQTYEAPIVVTGIKYSEDNLSHV
LSDADYLEIPTRRRNFTISFAALDYTNSLDIEYAYKLDDNQWYYIGKKNSVSFVSLPAGK
YQFQIKATNGDGIWMNTVKTVTLQVLPTFWETGWAKAFYLVVVLVISLAIGYIFFYIYYL
KHKVNMEQRLAEIKVRSFIDISHELRTPLTLISGPVSEVLSQEPLTSRTRHHLQLVQKNI
NRMLLLINQVLDFRKIQNKKMGLTIEYRDIIIMLHNIMDNFRLLATEKNINFSLQTTLPS
VFLWIDSDKFEKIIFNLLSNAFKYTPDNKSITLIVMESGQFVSIAVKDEGIGISKDKVPS
IFERFTTVSKENDMQPSSGIGLSLVNELVKMLHGEIQVESEVKKGSVFKLVLHKGKEIYA
QDKNVEYILNDTSEEQETVLAEPEQNDKTSLPDMPPATKETLVKVMVVEDNAELRQFICE
ILSGTYRVVGVADGVMALEKIEEEIPDFIITDIMMPRMDGIELIRHIKENVNTCDIPLII
LSAKSSVEDRIQCLQLGIDDYIPKPFSSDYLKSRIENLIRQRKVLQSAFLSKYGAQPKKE
PLEAVAYPVSQIVPLDELFMQKLVGFMEENYSNPGLRVNDLAEFMNMSRSVFNRKVNGIM
GISPIEYIKNYRLNKAKSFIQSGMSFSEVAFAVGFSDPGYFGKAFKKAFNQTLTEYKNNN