Protein Info for HMPREF1058_RS02430 in Phocaeicola vulgatus CL09T03C04

Annotation: HAMP domain-containing histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 498 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details transmembrane" amino acids 246 to 271 (26 residues), see Phobius details PF02518: HATPase_c" amino acids 394 to 497 (104 residues), 68 bits, see alignment E=4.9e-23

Best Hits

KEGG orthology group: None (inferred from 100% identity to bvu:BVU_0315)

Predicted SEED Role

"Two-component system sensor histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I8ZGC6 at UniProt or InterPro

Protein Sequence (498 amino acids)

>HMPREF1058_RS02430 HAMP domain-containing histidine kinase (Phocaeicola vulgatus CL09T03C04)
MKKILLTLALAFCCAAGQGQTTAKPADVNIQELNTKWAKFTQYAEQKQINKAVEEGIRIS
TLFTQNRQYKEAFATCRQMDALIYYNEQEKKSPEYKLRFMVGKERLRMYTNLKNTEQCKI
LLKQLHSYTDQLKSDSLQEELLMTEANYYQTFGMTDKSLECYNILFQKRSAGKDEKGIDQ
CYKDMLGYAEQNNNAPLAIAMRKLYTSWQDSIKAVKTANELNTLQQKYETSQKTLQEKED
KITTNLIIIIALCVLSAILAAGLLFLATLLFKHIRQVKKLKHSLQIANENNEQKSKFIGN
ISAQIEPSLNTIDEATKETISTPILHENIKALKELMTAIQTYISLEETREEHYPLKELNI
NTLCESIMEKAKINFKSGVEAVVNVPRVNIKTNAEELERILNHLLNNAAEYTKSGKISLE
FKKRSAHTHQFILTDTGTGIPVEAREKLFKPFAEIRDLTQGNGLGLPTCSLIAYKLNGTL
TLDTDYKKGTRFILELHV