Protein Info for HMPREF1058_RS02240 in Phocaeicola vulgatus CL09T03C04

Annotation: MATE family efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 456 transmembrane" amino acids 19 to 39 (21 residues), see Phobius details amino acids 43 to 44 (2 residues), see Phobius details amino acids 51 to 83 (33 residues), see Phobius details amino acids 97 to 119 (23 residues), see Phobius details amino acids 139 to 160 (22 residues), see Phobius details amino acids 171 to 191 (21 residues), see Phobius details amino acids 197 to 217 (21 residues), see Phobius details amino acids 237 to 262 (26 residues), see Phobius details amino acids 274 to 295 (22 residues), see Phobius details amino acids 318 to 339 (22 residues), see Phobius details amino acids 358 to 379 (22 residues), see Phobius details amino acids 392 to 412 (21 residues), see Phobius details amino acids 418 to 439 (22 residues), see Phobius details TIGR00797: MATE efflux family protein" amino acids 25 to 420 (396 residues), 191 bits, see alignment E=1.6e-60 PF01554: MatE" amino acids 25 to 186 (162 residues), 96.6 bits, see alignment E=1.3e-31 amino acids 252 to 400 (149 residues), 71.4 bits, see alignment E=7.4e-24 PF14667: Polysacc_synt_C" amino acids 140 to 294 (155 residues), 33.9 bits, see alignment E=3.3e-12

Best Hits

KEGG orthology group: None (inferred from 100% identity to bvu:BVU_0273)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9TWH2 at UniProt or InterPro

Protein Sequence (456 amino acids)

>HMPREF1058_RS02240 MATE family efflux transporter (Phocaeicola vulgatus CL09T03C04)
MAKTGTPTELGTQPIGKLLLQYAIPAIIAMTASSLYNMVDSIFIGHGVGPLAISGLAITF
PLMNLAAAFGSLVGVGASTLVSVKLGQKDYATAQNILGNVVTLNFIIGIGFSILTLLFLD
PILYFFGASPDTISYARDYMVIILLGNVITHMYLGLNALLRASGHPQKAMTATITTVIIN
TILDPIFIYLFHWGIQGAAIATILAQIISLVWQFKTFTNKNELLHLRRGIYKLRGTIVKN
TIAIGMSPFLMNLAACFIVIFINKGLKEYDGDLAIGAFGIVNRIVFLFVMIVMGLNQGMQ
PIAGYNFGAQQYHRVNQVLKLTIYGATAVTTTGFLVGELMPELAVSAFTTHEGLIQLSAT
GLRIVVIFFPIIGFQMVTSNFFQSIGMAGKAIFLSLTRQLLFLLPSIILLPLCWGSAGIW
WSMPISDLAASVVAGIMLYRQFKIFKTHGNKLKVEN