Protein Info for HMPREF1058_RS02230 in Phocaeicola vulgatus CL09T03C04

Annotation: exodeoxyribonuclease VII large subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 435 PF13742: tRNA_anti_2" amino acids 6 to 114 (109 residues), 61.7 bits, see alignment E=6.7e-21 TIGR00237: exodeoxyribonuclease VII, large subunit" amino acids 7 to 432 (426 residues), 345.8 bits, see alignment E=1.8e-107 PF02601: Exonuc_VII_L" amino acids 140 to 430 (291 residues), 265.8 bits, see alignment E=6.5e-83

Best Hits

KEGG orthology group: K03601, exodeoxyribonuclease VII large subunit [EC: 3.1.11.6] (inferred from 100% identity to bvu:BVU_0271)

Predicted SEED Role

"Exodeoxyribonuclease VII large subunit (EC 3.1.11.6)" in subsystem DNA repair, bacterial (EC 3.1.11.6)

Isozymes

Compare fitness of predicted isozymes for: 3.1.11.6

Use Curated BLAST to search for 3.1.11.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9TX97 at UniProt or InterPro

Protein Sequence (435 amino acids)

>HMPREF1058_RS02230 exodeoxyribonuclease VII large subunit (Phocaeicola vulgatus CL09T03C04)
MEEHPLSLYELNALVKRSIHACLPDTYWVQAELSDVRSNYSGHCYLEFVQKEPRGNNLIA
KARGTIWSNVYRLLKPYFEEETGQAFVAGIKVMVKVAVEFHELYGYSLTVQDIDPTYTLG
DMARRRREILKQLEEEGVLTLNKELEIPLLAQRIAVISSATAAGYGDFCNQLEQNPYGFV
FYPRLFPAIMQGERVEQSVITALDAIHACRDDWDVVVIIRGGGATSDLSGFDTYELAANC
AQFPIPIITGIGHERDDTVLDCVSHTRVKTPTAAAEYLINHLHDTAKVLEDYASAVLHTI
STRMERENTRLNRMVERIPMQTRMRLKEEHYRQERIMKHLEVGLQSRLTKETHCLKMMET
RLGIVSQRRLVKEKHRLQLLEQELKAASPENLLKRGYSITLKNGKAVIDASVLQPGDELT
TRFAKGEIKSIVTKK