Protein Info for HMPREF1058_RS01480 in Phocaeicola vulgatus CL09T03C04
Annotation: ribonucleoside-diphosphate reductase subunit alpha
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 66% identical to RIR1_TREPA: Ribonucleoside-diphosphate reductase subunit alpha (nrdA) from Treponema pallidum (strain Nichols)
KEGG orthology group: K00525, ribonucleoside-diphosphate reductase alpha chain [EC: 1.17.4.1] (inferred from 100% identity to bvu:BVU_3098)Predicted SEED Role
"Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)" in subsystem Ribonucleotide reduction (EC 1.17.4.1)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
- superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
- superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (16/18 steps found)
- superpathway of purine nucleotide salvage (13/14 steps found)
- superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis I (8/9 steps found)
- superpathway of adenosine nucleotides de novo biosynthesis I (5/5 steps found)
- superpathway of guanosine nucleotides de novo biosynthesis II (7/8 steps found)
- superpathway of adenosine nucleotides de novo biosynthesis II (6/7 steps found)
- adenosine deoxyribonucleotides de novo biosynthesis I (2/2 steps found)
- guanosine deoxyribonucleotides de novo biosynthesis I (2/2 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis III (7/9 steps found)
- pyrimidine deoxyribonucleotides biosynthesis from CTP (6/8 steps found)
- adenosine deoxyribonucleotides de novo biosynthesis II (3/4 steps found)
- guanosine deoxyribonucleotides de novo biosynthesis II (3/4 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis IV (5/7 steps found)
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (10/14 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.17.4.1
Use Curated BLAST to search for 1.17.4.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See I8ZDL2 at UniProt or InterPro
Protein Sequence (839 amino acids)
>HMPREF1058_RS01480 ribonucleoside-diphosphate reductase subunit alpha (Phocaeicola vulgatus CL09T03C04) MQIIKRNGTTESYDREKIAVAIRKSFISTQKEITDEAVYTIVDEVEQFLHQNEANRSVER IQDEVERSLMEHGFYAEAKNYILYRWQRTERRKVLSQIITGTGDDTIANILKEIQKDFSG KEYSLTFLAEKFTSFCKPDMTSGERLAALVKAAVELTTQETPDWEFIAARLLNFRLTKKL TEQAEAAGIFSFYDKLRYLTDEGLYGNYILASYTPQEIETAAGFMCPERDKLFNYSGLDL LAKRYLIRTRSHEPIESVQEMYLGIALHLAMPEKQNRLQWVKKFYDILSRLEVTMATPTL ANARKPYHQLSSCFIDTVPDSLEGIYRSLDNFAMVSKFGGGMGMYFGKVRAAGGNIRGFK GVAGGVIRWMKLVNDTAVAVDQLGMRQGAVAVYLDVWHKDLPEFLQLRTNNGDDRMKAHD IFPAVCYPDLFWRMAKRDLNQQWHLFCPNEIMTVKGYCLEDYYGEEWEQRYMDCVNDSRL SKRCMSIKDIVRLVLRSAVETGTPFTFNRDTVNRANPNAHRGIIYCSNLCTEIAQNMSSI ETVSTEICTEDGDTVVVKTIRPGDFVVCNLASLSLGHLPLEDEKQMKEKVATVVRALDNV IELNFYPIPFAQITNHRYRSIGLGVSGYHHALAVRGIRWESEEHLNFMDKVFERINYAAI AASSELAKEKGAYHYFEGSDWQTGAYFIKRGYNSPEWKALAVKVSTQGMRNAYLLAIAPT SSTSIIAGTTAGTDPVMKRFFLEEKKGAMLPRVAPALSDKTYWIYKSAYLTDQTWSIRAA GIRQLHIDQAQSLNLYITNEFTLRQVLNLYLLAWECGVKTVYYVRSKSLEVEECESCAS