Protein Info for HMPREF1058_RS00510 in Phocaeicola vulgatus CL09T03C04

Annotation: guanylate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03263: guanylate kinase
  • amino acids 4 to 184 (181 residues), 220.8 bits, E=5.3e-70
• PF00625: Guanylate_kin
  • amino acids 4 to 181 (178 residues), 149.8 bits, E=7.4e-48

Best Hits

Swiss-Prot: 84% identical to KGUA_BACFN: Guanylate kinase (gmk) from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)

KEGG orthology group: K00942, guanylate kinase [EC: 2.7.4.8] (inferred from 100% identity to bvu:BVU_1644)

MetaCyc: 44% identical to guanylate kinase (Escherichia coli K-12 substr. MG1655)
Guanylate kinase. [EC: 2.7.4.8]; T(2)-induced deoxynucleotide kinase. [EC: 2.7.4.8, 2.7.4.12, 2.7.4.13]

Predicted SEED Role

"Guanylate kinase (EC 2.7.4.8)" in subsystem MLST or Purine conversions (EC 2.7.4.8)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (16/18 steps found)
• superpathway of purine nucleotide salvage (13/14 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (8/9 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis II (7/8 steps found)
• guanosine ribonucleotides de novo biosynthesis (4/4 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (7/9 steps found)
• superpathway of pyrimidine deoxyribonucleoside salvage (7/9 steps found)
• dZTP biosynthesis (4/5 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (6/8 steps found)
• pyrimidine deoxyribonucleotide phosphorylation (3/4 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (5/7 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (10/14 steps found)
• purine deoxyribonucleosides salvage (4/6 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis II (3/7 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.4.12 or 2.7.4.13 or 2.7.4.8

Sequence Analysis Tools

See I8ZBI5 at UniProt or InterPro

Protein Sequence (189 amino acids)

>HMPREF1058_RS00510 guanylate kinase (Phocaeicola vulgatus CL09T03C04)
MATGKLIIFSAPSGSGKSTIINYLLTQNLNLSFSISATSRPPRGKERHGVEYFFLSPEEF
RQRIANNEFLEYEEVYENRFYGTLKAQVEKQLEAGQNVIFDVDVVGGCNIKKYYGSRALS
VFIQPPSVEELRKRLQGRGTDAPEVIESRIAKAEFELGFADKFDTVIVNDDLEKAKAEAL
KVIRNFIEQ