Protein Info for HMPREF1058_RS00470 in Phocaeicola vulgatus CL09T03C04

Annotation: redox-sensing transcriptional repressor Rex

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 216 PF06971: Put_DNA-bind_N" amino acids 11 to 59 (49 residues), 69 bits, see alignment E=3e-23 PF02629: CoA_binding" amino acids 88 to 184 (97 residues), 79.5 bits, see alignment E=2.7e-26

Best Hits

Swiss-Prot: 84% identical to REX_BACFN: Redox-sensing transcriptional repressor Rex (rex) from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)

KEGG orthology group: K01926, AT-rich DNA-binding protein (inferred from 100% identity to bvu:BVU_1637)

Predicted SEED Role

"Redox-sensitive transcriptional regulator (AT-rich DNA-binding protein)" in subsystem Oxidative stress

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I9TU45 at UniProt or InterPro

Protein Sequence (216 amino acids)

>HMPREF1058_RS00470 redox-sensing transcriptional repressor Rex (Phocaeicola vulgatus CL09T03C04)
MDIRMHKFSDKVPEPTLRRLPWYLSNVKLMKEQGETYVSSTQISKQINVDASQIAKDLSY
VNISGRTRVGYEIDALIEVLERFLGFTKMHKAFLFGVGSLGGALLRDSGLHHFGLEIVGA
FDINPGLVGKEINGIPIYHSDEFEIKMKSCDVNIGVLTVPINIAQEITDKMIAGGIKAVW
NFTPFRIRVPENIVVQNTSLYAHLAVMFNRLNVIQE