Protein Info for H281DRAFT_06351 in Paraburkholderia bryophila 376MFSha3.1

Annotation: succinate semialdehyde dehydrogenase (EC 1.2.1.16)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 21 to 483 (463 residues), 555.8 bits, E=3.4e-171

Best Hits

Swiss-Prot: 56% identical to DAVD_PSEPK: Glutarate-semialdehyde dehydrogenase (davD) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 94% identity to bgf:BC1003_4348)

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

• 4-aminobutanoate degradation III (2/2 steps found)
• methylglyoxal degradation V (2/3 steps found)
• L-lactaldehyde degradation (aerobic) (1/2 steps found)
• lactate biosynthesis (archaea) (3/5 steps found)
• L-rhamnose degradation II (5/8 steps found)
• methylglyoxal degradation IV (1/3 steps found)
• superpathway of methylglyoxal degradation (4/8 steps found)
• superpathway of fucose and rhamnose degradation (5/12 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Pyruvate metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16, 1.2.1.22

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.22

Sequence Analysis Tools

See A0A2Z5MNN1 at UniProt or InterPro

Protein Sequence (491 amino acids)

>H281DRAFT_06351 succinate semialdehyde dehydrogenase (EC 1.2.1.16) (Paraburkholderia bryophila 376MFSha3.1)
MSLALTRNELIRPLNFIGGKWIAAANGARFPVTNPATGDTIVEVANSSAADARAATDAAA
SALPAWRGKLPRERAEILRRWHALIVENTEDLAKLMSTEQGKPLAESRGEVAYGASYVAW
FADEATRIYGDIIPQQQRGKRMSAVKEAIGIVAAITPWNFPLAMIARKIAPALAAGCTVV
AKPAEDTPLTALALAALAQEAGVPDGVLNMLSASRDQGIEAVADWLADARVRKITFTGST
PVGKHLARESAATLKKLSLELGGNAPFIVFDDADLDAAVTGLMAAKFRNGGQTCVCPNRV
YVQAGVYERFADLLAKRVAALKVAPATDPSAQIGPMINERAIDKIARHVEDAVKQGAKVL
TGGKRLTELGPNYYAPTVLTDANDGMLVCCEETFGPVAPLFRFSDEAEAVRLANDTPFGL
AAYFFTQDVRRIDRVATRLEAGVIGINEGAVSSEVAPFGGVKESGYGREGSKYGLDDYLS
IKYLCQGGFDQ