Protein Info for H281DRAFT_06082 in Paraburkholderia bryophila 376MFSha3.1

Annotation: ATP-dependent Clp protease ATP-binding subunit ClpC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 944 PF02861: Clp_N" amino acids 137 to 184 (48 residues), 39.1 bits, see alignment 5.2e-13 amino acids 213 to 264 (52 residues), 53.9 bits, see alignment 1.2e-17 PF00004: AAA" amino acids 324 to 439 (116 residues), 49.9 bits, see alignment E=3.4e-16 amino acids 664 to 785 (122 residues), 34.7 bits, see alignment E=1.7e-11 PF17871: AAA_lid_9" amino acids 465 to 566 (102 residues), 116.9 bits, see alignment E=2.8e-37 PF00158: Sigma54_activat" amino acids 654 to 792 (139 residues), 30.1 bits, see alignment E=2.8e-10 PF07724: AAA_2" amino acids 658 to 826 (169 residues), 221.9 bits, see alignment E=3.9e-69 PF07728: AAA_5" amino acids 663 to 786 (124 residues), 43 bits, see alignment E=3.4e-14 PF10431: ClpB_D2-small" amino acids 832 to 911 (80 residues), 82.7 bits, see alignment E=1.2e-26

Best Hits

KEGG orthology group: K03696, ATP-dependent Clp protease ATP-binding subunit ClpC (inferred from 94% identity to bpy:Bphyt_5492)

Predicted SEED Role

"ATP-dependent Clp protease ATP-binding subunit ClpA" in subsystem Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MKH6 at UniProt or InterPro

Protein Sequence (944 amino acids)

>H281DRAFT_06082 ATP-dependent Clp protease ATP-binding subunit ClpC (Paraburkholderia bryophila 376MFSha3.1)
MAECSVCGKPATSQITITENGQRRQLMLCDQHYMEFMARNQRRLSPLESLFHGGLFESLF
DDMWPQMEDDRGSRSRIRRAPGQSGGAEQDTGTGSGQIGDSAGGQSGGRTRRHRRAREAV
DLQTYLSQSGLDRLQAAAQAAVEYGKNEVDTEHLLLALADNNVVQEVLREFKLDPEEIKK
TIDQTAPRGTRKEPSDNEQIGVSPRAKSALENALKASQELGHSYVGPEHILIGLVEEEDG
FAGELLRKLGLSSPSLRQKAVKVVGQGAEDGKMEGRSTTPTLDKYARDLSALARQGKLDP
VIGRDKEIETTIEVLARRRKNNPVLIGEPGVGKTAIVEGLAQRIAQDQVPEVLRGKRVVE
LNINSVVAGAKYRGEFEERVKQVLDEIIENQDRLVVFIDELHTIVGAGQGGGEGGLDIGN
VFKPALARGELHLVGATTLNEYQKYIEKDSALERRFQPVMVPEPSVEETIEILRGLRDRL
EAHHKVKITEEAIDAAAKLSDRYIAARFLPDKAIDLLDQAAARVRISSNSRPQPLHDVEA
TIRRIKQEQDAASAAKKFDKAKELEERLVTEQKRLHEATETWKKERGTSSQEVTAEDIAQ
IVSSLTGVPLAELTAQDREKLLRLEDRLKERVVGQDEAVSAVAKAVRLSRAGLTEAGKPT
ASFLFLGPTGVGKTELAKALAASVFGDENALVRIDMSEYSERHTVARLVGAPPGYVGYEE
GGQLTERVRRRPYCVVLLDEIEKAHSEVHNLLLQLFDEGRLTDGKGRLVDFTNTIIIATS
NVGSQVIQDNMKADSKQLDYPALRDRLMEILRHHFKPEFLNRVDEVVVFHALGKEQIRSI
VDLQLARVRRTALAQGIDLSFDDGLRDHLAQIGYDPEFGARMLKRKIRLEVESQLADALL
RGDVRDGDKVTMTYDSGTHSVRVQKGATPAEAPSEAPKQAPAHA