Protein Info for H281DRAFT_06064 in Paraburkholderia bryophila 376MFSha3.1

Annotation: acetyl-CoA carboxylase carboxyltransferase subunit beta /acetyl-CoA carboxylase carboxyltransferase subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00515: acetyl-CoA carboxylase, carboxyl transferase, beta subunit
  • amino acids 1 to 285 (285 residues), 428.9 bits, E=4.7e-133
• PF17848: zf-ACC
  • amino acids 28 to 53 (26 residues), 51.3 bits, see alignment (E = 1.1e-17)
• PF01039: Carboxyl_trans
  • amino acids 108 to 243 (136 residues), 56.5 bits, E=2.1e-19

Best Hits

Swiss-Prot: 97% identical to ACCD_PARP8: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD) from Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)

KEGG orthology group: K01963, acetyl-CoA carboxylase carboxyl transferase subunit beta [EC: 6.4.1.2] (inferred from 99% identity to bug:BC1001_4907)

MetaCyc: 63% identical to acetyl-CoA carboxyltransferase subunit beta (Escherichia coli K-12 substr. MG1655)
RXN0-5055 [EC: 2.1.3.15]

Predicted SEED Role

"Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2)" in subsystem Fatty Acid Biosynthesis FASII (EC 6.4.1.2)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (50/53 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (14/17 steps found)
• biotin-carboxyl carrier protein assembly (4/4 steps found)
• fatty acid biosynthesis initiation (type II) (3/3 steps found)
• superpathway of fatty acid biosynthesis initiation (4/5 steps found)
• propanoyl CoA degradation I (2/3 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (7/10 steps found)
• 2-oxobutanoate degradation I (2/4 steps found)
• fatty acid biosynthesis initiation (type I) (1/3 steps found)
• 3-hydroxypropanoate cycle (8/13 steps found)
• methylaspartate cycle (12/19 steps found)
• superpathway of the 3-hydroxypropanoate cycle (10/18 steps found)
• candicidin biosynthesis (1/6 steps found)
• glyoxylate assimilation (6/13 steps found)
• jadomycin biosynthesis (3/9 steps found)
• superpathway of candicidin biosynthesis (4/11 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (9/18 steps found)
• superpathway of L-methionine salvage and degradation (7/16 steps found)
• superpathway of mycolate biosynthesis (26/239 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis
• Propanoate metabolism
• Pyruvate metabolism
• Tetracycline biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 6.4.1.2

Use Curated BLAST to search for 2.1.3.15 or 6.4.1.2

Sequence Analysis Tools

See A0A2Z5MMG4 at UniProt or InterPro

Protein Sequence (290 amino acids)

>H281DRAFT_06064 acetyl-CoA carboxylase carboxyltransferase subunit beta /acetyl-CoA carboxylase carboxyltransferase subunit alpha (Paraburkholderia bryophila 376MFSha3.1)
MSWLDKLLPPKIKQTDPKNRKGIPEGLWIKCPSCEAVLYRNDVEANLHVCPKCDHHMRIG
ARERLDGLLDPEGRYEIGQEIVPVDALKFKDSRKYPDRLKEAMDDTDETDAMVVMGGAIH
TLPVVVACFEFSFMGGSMGSVVGERFARGAQNALEQKVPFICFTASGGARMQESLLSLMQ
MAKTTAMLTKLAEAKLPFISVLTDPTMGGVSASFAFLGDVVIAEPKALIGFAGPRVIEQT
VREKLPEGFQRAEFLLTKGAIDMIVDRRKLREELAQLMALLSHQPADAVA