Protein Info for H281DRAFT_06022 in Paraburkholderia bryophila 376MFSha3.1

Annotation: DNA polymerase I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 913 transmembrane" amino acids 749 to 761 (13 residues), see Phobius details PF02739: 5_3_exonuc_N" amino acids 11 to 173 (163 residues), 188.1 bits, see alignment E=2e-59 TIGR00593: DNA polymerase I" amino acids 12 to 913 (902 residues), 904.3 bits, see alignment E=5.4e-276 PF01367: 5_3_exonuc" amino acids 174 to 261 (88 residues), 88 bits, see alignment E=1e-28 PF01612: DNA_pol_A_exo1" amino acids 316 to 501 (186 residues), 107 bits, see alignment E=1.9e-34 PF00476: DNA_pol_A" amino acids 535 to 911 (377 residues), 529.5 bits, see alignment E=9.3e-163

Best Hits

KEGG orthology group: K02335, DNA polymerase I [EC: 2.7.7.7] (inferred from 82% identity to bac:BamMC406_3769)

Predicted SEED Role

"DNA polymerase I (EC 2.7.7.7)" in subsystem DNA-replication or DNA Repair Base Excision (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MKT4 at UniProt or InterPro

Protein Sequence (913 amino acids)

>H281DRAFT_06022 DNA polymerase I (Paraburkholderia bryophila 376MFSha3.1)
MPEERSLEGKTLLLVDGSSYLYRAYHAMPDLRGPDGGPTGALYGMINMLRRMRKEVTAEY
SACVFDAKGKTFRDDWYPDYKANRPSMPDDLSRQIEPIHVAVRALGWPLLMIDGVEADDV
IGTLSTEAEKRGMNVIVSTGDKDLAQLVSDHVTLINTMTNEKLDRAGVLAKFGVPPERIV
DYLSLIGDTVDNVPGVEKCGPKTALKWLSQFESLDGIVAHADEIKGAVGDNLRRALDFLP
MARKLVTVERHCDLTGHLTSIEENLQSRPESREELRDVFTRHGFKTWLREVEIADAVEGP
ETDVPPALSVDHERHYETVQTWEQFDAWLQKINAAGLTSFDTETTSLDPMTAQIVGLSLS
VEAGHAAYVPLAHRGPDAPVQLPRDEVLARLKPWLESAEYKKVGQHLKYDEQVLANYGIE
MRGVEHDTLLQSYVLESHRPHDMDNLALRHLGIKTIKYEDVAGKGAQQIGFDEVALDKAA
EYAAEDADVTLRLHQALYPQLAAEEALEHVYRDIEVPTSRVLRKMERTGVLIDAEKLRQQ
SSEIAARLIQLESEAYVLAGGEFNLGSPKQIGQIFFERLELPVVKKTPSGAPSTDEEVLQ
KLAEDYPLPKILLEHRGLSKLKSTYTDKLPRMVNATTGRVHTNYAQAVAVTGRLASNDPN
LQNIPVRTGEGRRIREAFIAPPGHKLVSADYSQIELRIMAHISGDESLLRAFSQGEDIHR
ATAAEIFSVTPLEVSNDQRRVAKVINFGLIYGMSSFGLASNLGITRDAAKLYIDRYFARY
PGVARYMDETRLSAKAKGYVETVFGRRLWLPEINGGNGPRRQAAERAAINAPMQGTAADL
IKLSMIAVQKWIEQARIGTRMIMQVHDELILEVPDAELSEVHQRLPELMCGVAALKVPLV
AEVGAGLNWEEAH