Protein Info for H281DRAFT_06018 in Paraburkholderia bryophila 376MFSha3.1

Annotation: choline monooxygenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00355: Rieske
  • amino acids 52 to 122 (71 residues), 46.6 bits, E=2.6e-16
• PF00848: Ring_hydroxyl_A
  • amino acids 173 to 364 (192 residues), 137.1 bits, E=8.1e-44

Best Hits

KEGG orthology group: K00499, choline monooxygenase [EC: 1.14.15.7] (inferred from 97% identity to bpy:Bphyt_6784)

MetaCyc: 60% identical to hydroxy-succinyl-putrescine hydroxylase (Bordetella bronchiseptica)
RXN-11010

Predicted SEED Role

"GbcA Glycine betaine demethylase subunit A" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis

MetaCyc Pathways

• glycine betaine biosynthesis III (plants) (3/3 steps found)
• alcaligin biosynthesis (1/5 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.14.15.7

Sequence Analysis Tools

See A0A2Z5MKZ8 at UniProt or InterPro

Protein Sequence (368 amino acids)

>H281DRAFT_06018 choline monooxygenase (Paraburkholderia bryophila 376MFSha3.1)
MSNLSNALQLRSVHSQLPVTAYFDEALLTREIETLFRKGPRYVGHDLMVPEAGNYFALPS
ESEGRVLVRNQQSQVELLSNVCRHRQAIMLNGRGHAENIVCPLHRWTYDLNGQLLGAPHF
ADNPCLNLGATPLQNWQGLLFEAQGRNVARDLANLGTKRHFDFSGFMFDHVEVHECNYNW
KTFIEVYLEDYHVAPFHPGLGSFVNCDDLTWEFGEWYSVQTVGVHKDLEQPGSPTYRKWH
DEVLRFRGGTPPEFGAIWMVYYPGIMIEWYPHVLVVSWLIPRGPQKTTNVVEFYYPEEIA
LFEREFVEAERAAYMETAREDDEIAERMDAGRRALMERGESQVGPYQSPMEDGMQHFHEF
LRRELGTI